| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M106399-1g |
1g |
现货  |
|
| 别名 | (R)-(+)-alpha-甲氧基-alpha-三氟甲基苯乙酸 | Mosher 酸 | (R)-(+)-α-甲氧基-α-三氟甲基苯乙酸 |
|---|---|
| 英文别名 | (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid | M0831 | (+)-alpha-methoxy-alpha-trifluoromethylphenylacetic acid | SB35195 | EINECS 243-829-5 | (R)-(+)-Mosher's acid | Benzeneacetic acid, a-methoxy-a-(trifluoromethyl)-, (aR)- | (+)-Mtpa | MOSHER'S |
| 规格或纯度 | 99% |
| 英文名称 | Mosher’s acid |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Mosher 酸性氯化物通常用作手性衍生剂。它易于获得的对映体纯形式。它可以与醇类和胺类形成非对映异构体。 A derivatizing reagent used for the determination of enantiomeric excess by NMR. Mosher’s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines. A derivatizing reagent used for the determination of enantiomeric excess by NMR. (R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis, an NMR-based method for determining the absolute configuration of the chiral carbon center in a secondary alcohol. |
| EC号 | 243-829-5 |
|---|---|
| IIUPAC Name | (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid |
| INCHI | 1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m1/s1 |
| InChi Key | JJYKJUXBWFATTE-SECBINFHSA-N |
| Smiles | COC(C1=CC=CC=C1)(C(=O)O)C(F)(F)F |
| Isomeric SMILES | CO[C@](C1=CC=CC=C1)(C(=O)O)C(F)(F)F |
| 分子量 | 234.17 |
| Beilstein号 | 3591560 |
| Reaxy-Rn | 2215439 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2215439&ln= |
| 溶解性 | Soluble in methanol (50 mg/ 1 ml). |
|---|---|
| 密度 | 1.344 |
| 敏感性 | 易吸潮 |
| 折光率 | 1.473 |
| 比旋光度 | 72 ° (C=2, MeOH) |
| 闪点(℉) | 235.4 °F |
| 闪点(℃) | 110 °C |
| 沸点 | 105-107°C |
| 熔点 | 46-49°C |
| 分子量 | 234.170 g/mol |
| XLogP3 | 2.300 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 234.05 Da |
| 单同位素质量Monoisotopic Mass | 234.05 Da |
| 拓扑极表面积Topological Polar Surface Area | 46.500 Ų |
| 重原子数Heavy Atom Count | 16 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 259.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| 1. J Martín Torres-Valencia,Guadalupe I León,J Roberto Villagómez-Ibarra,Oscar R Suárez-Castillo,Carlos M Cerda-García-Rojas,Pedro Joseph-Nathan. (2002-12-24) Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters.. Phytochemical analysis : PCA, 13 ((6)): (329-332). [PMID:12494750] |
| 2. Osamu Shirota,Yukihiro Kaida,Setsuko Sekita. (2004-02-24) [Three dimensional structure analysis of organic chemical compounds from natural sources using NMR spectral analysis].. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, ((121)(121)): (87-88). [PMID:14977004] |
| 3. Giancarlo Cravotto,Carlo Bicchi,Silvia Tagliapietra,Luisa Costa,Stefano Di Carlo,Carlo Nervi. (2004-08-04) New chiral selectors: design and synthesis of 6-TBDMS-2,3-methyl beta-cyclodextrin 2-2' thioureido dimer and 6-TBDMS-2,3-methyl (or 2-methyl-3-acetyl) beta-cyclodextrin bearing an (R) Mosher acid moiety.. Chirality, 16 ((8)): (526-533). [PMID:15290688] |
| 4. Barry J Everitt,Trevor W Robbins. (2005-10-28) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.. Nature neuroscience, 8 ((11)): (1481-1489). [PMID:16251991] |
| 5. Lidia De Luca,Giampaolo Giacomelli,Giammario Nieddu. (2007-04-11) A facile approach to the synthesis of chiral 2-substituted benzofurans.. The Journal of organic chemistry, 72 ((10)): (3955-3957). [PMID:17419648] |
| 6. Thomas R Hoye,Christopher S Jeffrey,Feng Shao. (2007-10-20) Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.. Nature protocols, 2 ((10)): (2451-2458). [PMID:17947986] |
| 7. Thomas R Hoye,Sara E Erickson,Sherrie L Erickson-Birkedahl,Christopher R H Hale,Enver Cagri Izgu,Michael J Mayer,Patrick K Notz,Matthew K Renner. (2010-03-27) Long-range shielding effects in the (1)H NMR spectra of Mosher-like ester derivatives.. Organic letters, 12 ((8)): (1768-1771). [PMID:20337423] |
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