Larazotide acetate, 神经元乙酰胆碱受体；α3/β4 部分激动剂

COA

级别和纯度:

≥98%

CAS编号: 881851-50-9
分子式: C₃₄H₅₉N₉O₁₂
分子量: 785.89
PubChem编号: 44146842

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
L646246-1mg	1mg	期货
L646246-5mg	5mg	期货
L646246-10mg	10mg	期货
L646246-25mg	25mg	期货

查看相关系列

Cytoskeleton (497) Gap Junction Protein (15)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

别名	醋酸拉唑肽
英文别名	F77451 \| Larazotide acetate \| Glycine, glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolyl-, monoacetate \| UNII-FO8S2IW40N \| Larazotide acetate [USAN] \| DTXSID401007986 \| FO8S2IW40N \| D09352 \| Q25327025 \| Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-gl
规格或纯度	≥98%
英文名称	Larazotide acetate
生化机理	醋酸拉拉唑肽是一种多肽，是一种口服活性佐宁拮抗剂。醋酸拉拉唑肽对水痘-带状疱疹病毒（VZV）具有抗病毒活性，对 OKA 株和 07-1 株的 EC 50 s 分别为 44.14 和 59.06 μM。醋酸拉拉唑肽可
储存温度	干燥,-80℃储存
运输条件	超低温冰袋运输
作用类型	部分激动剂
作用机制	神经元乙酰胆碱受体；α3/β4 部分激动剂
产品介绍	Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC 50 s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection . In Vitro Larazotide acetate (1-100 μM; 5 d) affects Vero cell growth. Larazotide acetate (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC 50 s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells. Larazotide acetate (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: Vero cell line Concentration: 1-100 μM Incubation Time: 5 days Result: Inhibited Vero cell growth with an CC 50 value of 82.5 μM. In Vivo Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: HLA-HCD4/DQ8 double transgenic miceDosage: 250 μg Administration: Intraperitoneal injection; 250 μg twice a week for 7 weeks Result: Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels. Form:Solid IC50& Target:Paracellular permeability
纯度	≥98%

名称和识别符

分子类型	蛋白质
IIUPAC Name	acetic acid;2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
INCHI	1S/C32H55N9O10.C2H4O2/c1-16(2)12-20(38-30(49)26(17(3)4)39-24(44)14-35-23(43)13-33)28(47)40-27(18(5)6)31(50)37-19(9-10-22(34)42)32(51)41-11-7-8-21(41)29(48)36-15-25(45)46;1-2(3)4/h16-21,26-27H,7-15,33H2,1-6H3,(H2,34,42)(H,35,43)(H,36,48)(H,37,50)(H,38,49)(H,39,44)(H,40,47)(H,45,46);1H3,(H,3,4)/t19-,20-,21-,26-,27-;/m0./s1
InChi Key	NYGCNONRVCGHAT-UFIKZEAMSA-N
Smiles	CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)N1CCCC1C(=O)NCC(=O)O)NC(=O)C(C(C)C)NC(=O)CNC(=O)CN.CC(=O)O
Isomeric SMILES	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)CN.CC(=O)O
PubChem CID	44146842
分子量	785.89

化学和物理性质

溶解性	H2O : 16.67 mg/mL (21.21 mM; Need ultrasonic) DMSO : 3.2 mg/mL (4.07 mM; Need ultrasonic and warming)
分子量	785.900 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	10
氢键受体数Hydrogen Bond Acceptor Count	13
可旋转键计数Rotatable Bond Count	21
精确质量Exact Mass	785.428 Da
单同位素质量Monoisotopic Mass	785.428 Da
拓扑极表面积Topological Polar Surface Area	339.000 Å²
重原子数Heavy Atom Count	55
形式电荷Formal Charge	0
复杂度Complexity	1320.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	5
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度