基本描述

别名	谷氨酸钠一水合物
英文别名	L-Glutamic acid monosodium salt monohydrate \| 6106-04-3 \| MONOSODIUM GLUTAMATE \| Sodium glutamate \| monosodium l-glutamate monohydrate \| MFCD00150138 \| L-Glutamic acid, monosodium salt, monohydrate \| MSG monohydrate \| Sodium glutamate monohydrate \| Monosodium glutamate mon
规格或纯度	Moligand™, 10mM in Water
英文名称	L-Glutamic acid monosodium salt hydrate
生化机理	L-谷氨酸在发育、学习、记忆、可塑性和认知中起着关键作用。它在癫痫、精神分裂症、中风、缺血、ALS（肌萎缩侧索硬化症）、亨廷顿舞蹈病和帕金森病等神经病理疾病的发病机制中起着至关重要的作用。谷氨酸还参与长时程增强（LTP）和长时程抑制（LTD）的激活。谷氨酸受体诱导在偏头痛的病理生理学中起关键作用。
储存温度	-80℃储存
运输条件	超低温冰袋运输
产品介绍	L-谷氨酸是哺乳动物中枢神经系统（CNS）中主要的兴奋性神经递质。它与膜结合的谷氨酸受体相互作用。 L-谷氨酸单钠盐水合物被用作- • 大鼠海马切片培养物的化学调节剂，用于研究偏头痛发作前小胶质细胞的运动 • Neurobasal培养基的添加剂，用于培养从怀孕小鼠获得的胚胎神经元 • GYE（葡萄糖酵母提取物）固体培养基的成分，用于培养植物病原体叶缘焦枯病菌的四种菌株，即CVC克隆9a5c、Temecula（皮尔斯氏病）、Jab1（咖啡叶焦病）和分离株6747（李叶焦枯病），这一病原体会导致重要农作物生病 • 储备溶液的成分，用于平衡果蝇幼虫 • 腹神经节节段神经细胞内外[H+] RPMI（Roswell Park Memorial Institute）培养基1640的补充剂，用于供养每周传代两次的K562细胞培养物。 L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors. L-Glutamic acid monosodium salt hydrate has been used- • as a chemical modulator to rat hippocampal slice cultures for the study of microglial movement post spreading depression (SD) prior to migraine • as an additive to Neurobasal medium for the growth of embryonic neurons obtained from pregnant mice • as a component of GYE (glucose yeast extract) solid medium for the growth of four strains of phytopathogen Xylella fastidiosa namely, CVC clone 9a5c, Temecula (Pierce’s disease), Jab1 (Coffee Leaf Scorch), and the isolate 6747 (Plum Leaf Scald), which causes diseases in important crop plants • as a component of the stock solution for the equilibration of intracellular and extracellular [H+] in segmental nerves obtained from the ventral ganglion of Drosophila larvae • as a supplement to RPMI (Roswell Park Memorial Institute) medium 1640 used to maintain K562 cell cultures with twice-weekly passage.

名称和识别符

EC号	205-538-1
分子类型	小分子
IIUPAC Name	sodium;(4S)-4-amino-5-hydroxy-5-oxopentanoate;hydrate
INCHI	1S/C5H9NO4.Na.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1
InChi Key	GJBHGUUFMNITCI-QTNFYWBSSA-M
Smiles	C(CC(=O)[O-])C(C(=O)O)N.O.[Na+]
Isomeric SMILES	C(CC(=O)[O-])[C@@H](C(=O)O)N.O.[Na+]
关联CAS	142-47-2;32221-81-1
分子量	187.13
Beilstein号	4164348
Reaxy-Rn	4164348

化学和物理性质

比旋光度	25 ° (C=10, 2mol/L HCl)
熔点	232 °C (dec.) (lit.)
分子量	187.130 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	4
精确质量Exact Mass	187.046 Da
单同位素质量Monoisotopic Mass	187.046 Da
拓扑极表面积Topological Polar Surface Area	104.000 Å²
重原子数Heavy Atom Count	12
形式电荷Formal Charge	0
复杂度Complexity	149.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	3

安全和危险性（GHS）

WGK Germany	2
RTECS	MA1575000
Merck Index	6254
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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此产品的引用文献

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引用文献

1. Furong Jin, Xinyue Yin, Yang Wan, Jiukai Zhang, Jindi Wang, Xiangbo Fu, Tianxin Fu, Buwei Liu, Yongshi Chen, Bo Tian, Zhibiao Feng. (2023) Ultrasonic–microwave synergistic supramolecular solvent liquid–liquid microextraction of trace biogenic amines in fish and beer based on solidification of floating organic droplet. FOOD CHEMISTRY, 429 (136965). [PMID:37516607] [10.1016/j.foodchem.2023.136965]
2. Hongtong Hu, Yuyan Chang, Zhongjie Wang, Jiandong Cui, Shiru Jia, Yingjie Du. (2023) A chemo-biocatalyst based on glutamate oxidase-integrated biomimetic trimanganese tetraoxide as cascade composite nano-catalyst for synthesis of α‑Ketoglutaric acid. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 650 (1833). [PMID:37515973] [10.1016/j.jcis.2023.07.137]
3. Yu Miao, Chen Zhuoming, Xin Binjie, Liu Xunlin, Xu Wenjun. (2022) Multifunctional Polyacrylonitrile-based Pearl Nanofibrous Membrane Prepared by Electrospinning. FIBERS AND POLYMERS, 23 (11): (3022-3027). [10.1007/s12221-022-0059-9]
4. Jing Liu, Ninglong Zhang, Jiansen Li, Mingyang Li, Guangxian Wang, Wenli Wang, Yuxia Fan, Shui Jiang, Gaole Chen, Yin Zhang, Xia Sun, Yuan Liu. (2022) A novel umami electrochemical biosensor based on AuNPs@ZIF-8/Ti3C2 MXene immobilized T1R1-VFT. FOOD CHEMISTRY, 397 (133838). [PMID:35944333] [10.1016/j.foodchem.2022.133838]
5. Jun Yang, Shulin Hu, Anqi Liao, Yetian Weng, Shuli Liang, Ying Lin. (2022) Preparation of freeze-dried bioluminescent bacteria and their application in the detection of acute toxicity of bisphenol A and heavy metals. Food Science & Nutrition, 10 (6): (1841-1853). [PMID:35702313] [10.1002/fsn3.2800]
6. Mengdi Wang, Zhuoran Zhang, Qingqing Huo, Maolong Wang, Yong Sun, Hongling Liu, Jing Chang, Bin He, Yan Liang. (2022) Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy. ACS Applied Materials & Interfaces, 14 (9): (11092–11103). [PMID:35199981] [10.1021/acsami.1c22964]
7. Hui Chen, Han Zhang, Lixing Cao, Jinling Cui, Xuan Ma, Chong Zhao, Shutao Yin, Hongbo Hu. (2022) Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse. Cancers, 14 (2): (345). [PMID:35053507] [10.3390/cancers14020345]
8. Jieyao Yu, Yan Liu, Shaorong Zhang, Liyong Luo, Liang Zeng. (2021) Effect of brewing conditions on phytochemicals and sensory profiles of black tea infusions: A primary study on the effects of geraniol and β-ionone on taste perception of black tea infusions. FOOD CHEMISTRY, 354 (129504). [PMID:33756321] [10.1016/j.foodchem.2021.129504]
9. Juan Yue, Li Li, Peng Miao, Zheng Wang, Zhimin Chang, Dan Shao, Haohua Shao, Qian Mei, Shi-zhong Luo, Wen-Fei Dong. (2019) One-step synthesis of acriflavine-based carbon dots for adenine detection and a theoretical study on the detection mechanism. MICROCHEMICAL JOURNAL, 148 (73). [10.1016/j.microc.2019.04.041]
10. Yang Zhang, Ruixi Bai, Zhigang Zhao, Qiuxia Liao, Peng Chen, Wanghuan Guo, Chunqing Cai, Fan Yang. (2019) Highly selective and sensitive probes for the detection of Cr(VI) in aqueous solutions using diglycolic acid-functionalized Au nanoparticles. RSC Advances, 9 (19): (10958-10965). [PMID:35515295] [10.1039/C9RA00010K]
11. Huang Shuo, Zhong Ling, Li Shengnan, Liu Mingsheng, Zhang Zhao, Zhang Fengxiu, Zhang Guangxian. (2019) A novel monosodium-glutamate-based flame retardant containing phosphorus for cotton fabrics. CELLULOSE, 26 (4): (2715-2728). [10.1007/s10570-018-02241-8]
12. Dandan Yao, Lei Zhang, Jiaojiao Huang, Chenghong Sun, Yu Zhang, Xiaoli Gu, Chong-Zhi Wang, Fei Li, Lina Chen, Chun-Su Yuan. (2018) A surface magnetic imprinted polymers as artificial receptors for selective and efficient capturing of new neuronal nitric oxide synthase–post synaptic density protein-95 uncouplers. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 154 (180). [PMID:29550707] [10.1016/j.jpba.2018.03.003]
13. Canghao Ni, Changqing Sun, Zhaofeng Zhou, Yongli Huang, Xinjuan Liu. (2018) Surface tension mediation by Na-based ionic polarization and acidic fragmentation: Inference of hypertension. JOURNAL OF MOLECULAR LIQUIDS, 259 (1). [10.1016/j.molliq.2018.02.113]
14. Jiaojiao Huang, Chenghong Sun, Dandan Yao, Chong-Zhi Wang, Lei Zhang, Yu Zhang, Lina Chen, Chun-Su Yuan. (2018) Novel surface imprinted magnetic mesoporous silica as artificial antibodies for efficient discovery and capture of candidate nNOS–PSD-95 uncouplers for stroke treatment. Journal of Materials Chemistry B, 6 (10): (1531-1542). [PMID:32254217] [10.1039/C7TB03044D]
15. Xiaoli Gu, Jiaojiao Huang, Lei Zhang, Yu Zhang, Chong-Zhi Wang, Chenghong Sun, Dandan Yao, Fei Li, Lina Chen, Chun-Su Yuan. (2017) Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein-95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies. JOURNAL OF SEPARATION SCIENCE, 40 (17): (3522-3534). [PMID:28704580] [10.1002/jssc.201700595]
16. Jingwen Lan, Yiming Gong, Baining Lin, Airong Xu, Rukuan Liu. (2024) Designing high performance hydrogel sensor for real-time sensing applications. MICROCHEMICAL JOURNAL, (111272). [10.1016/j.microc.2024.111272]
17. Yingjie Du, Xiuyan Luo, Xiaohong Ye, Meijia Song, Yingjia Li, Shumao Yang, Caoxing Huang, Jiandong Cui. (2025) Molecular imprinted photoresponse hybrid biocatalyst for ultrasensitive glutamate detection. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 308 (142540). [PMID:40147642] [10.1016/j.ijbiomac.2025.142540]
18. Chen Yang, Kaikai Wei, Minghui Xu, Zhaojun Wang, Chuanjian Cui, Qianying Dai, Guijie Chen, Ruyan Hou. (2025) Sensory wheel construction and key flavor compounds characterization of black tea milk tea beverages. FOOD CHEMISTRY, 481 (143931). [PMID:40147384] [10.1016/j.foodchem.2025.143931]
19. Wenshuai Zhou, Haoran Qin, Qian Zhang, Jiaqi Cai, Hetong Qi, Honglan Qi. (2025) Single-Site Iridium Catalyst on Metal–Organic Framework as Light-Responsive Oxidase-Like Nanozyme with High Stability for Colorimetric Detection of Antioxidant Capacity. ANALYTICAL CHEMISTRY, 97 (12): (6555-6562). [PMID:40101180] [10.1021/acs.analchem.4c06063]

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L-谷氨酸钠,一水

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