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6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)

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货号 (SKU) 包装规格 是否现货 价格 数量
L131299-25mg
25mg 现货 Stock Image
L131299-100mg
100mg 期货 Stock Image
L131299-250mg
250mg 现货 Stock Image
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Fluorescent Dye (370)

基本描述

别名 2-(二甲氨基)-6-十二酰萘 | N,N-二甲基-6-十二酰-2-萘胺 | 劳丹
英文别名 Laurdan | Y97FBL93VW | N,N-Dimethyl-6-dodecanoyl-2-naphthylamine | AS-78851 | FT-0621105 | Laurdan | MFCD00467560 | 1-(6-(Dimethylamino)-2-naphthalenyl)-1-dodecanone | Q15426238 | 2-[(5S)-2,4-DIOXOTHIAZOLIDIN-5-YL]ACETATE | DTXSID80225517 | HY-D0080 | 1-D
规格或纯度 适用于荧光分析, ≥97%(HPLC)
英文名称 6-Dodecanoyl-N,N-dimethyl-2-naphthylamine
生化机理 6-十二碳酰基-N,N-二甲基-2-萘胺是一种荧光膜探针,用于磷脂多胶束聚集体,可区分相转变、相波动和相域共存。研究表明,糖磷脂中体积大、水合度高的极性头基与 6-十二碳酰基-N,N-二甲基-2-萘胺有良好的相互作用。荧光来自萘基,由于 2-二甲基氨基和 6-羰基残基之间存在部分电荷分离,因此萘基存在较小的偶极矩。这种荧光标签是研究偶极弛豫的理想选择,因为这种化合物会根据所处环境的不同而发出不同的光。例如,6-十二碳酰基-N,N-二甲基-2-萘胺在极性溶剂中发出红光,而在非极性溶剂中则发出蓝光。
储存温度 避光,-20°C储存,充氩
运输条件 超低温冰袋运输
产品介绍


fluorescence λex 366 nm; λem 497 nm in methanol
A fluorescent membrane probe,usually used to study membrane structure, order and dynamic processes such as fluidity.

纯度 ≥97%(HPLC)

名称和识别符

PubChem SID 504756594
IIUPAC Name 1-[6-(dimethylamino)naphthalen-2-yl]dodecan-1-one
INCHI 1S/C24H35NO/c1-4-5-6-7-8-9-10-11-12-13-24(26)22-15-14-21-19-23(25(2)3)17-16-20(21)18-22/h14-19H,4-13H2,1-3H3
InChi Key JHDGGIDITFLRJY-UHFFFAOYSA-N
Smiles CCCCCCCCCCCC(=O)C1=CC2=C(C=C1)C=C(C=C2)N(C)C
Isomeric SMILES CCCCCCCCCCCC(=O)C1=CC2=C(C=C1)C=C(C=C2)N(C)C
分子量 353.54
Reaxy-Rn 7379104
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7379104&ln=

化学和物理性质

溶解性 Solubility: Soluble in DMF, Acetonitrile, and Methanol
敏感性 对光线敏感
分子量 353.500 g/mol
XLogP3 8.100
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 12
精确质量Exact Mass 353.272 Da
单同位素质量Monoisotopic Mass 353.272 Da
拓扑极表面积Topological Polar Surface Area 20.300 Ų
重原子数Heavy Atom Count 26
形式电荷Formal Charge 0
复杂度Complexity 392.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

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批号(Lot Number) 证书类型 货号
H2514134 分析证书 L131299
J2326686 分析证书 L131299
J2326689 分析证书 L131299
J2326690 分析证书 L131299
J2326693 分析证书 L131299
J2326687 分析证书 L131299
J1931158 分析证书 L131299

此产品的引用文献

引用文献

1. Yang Xiaoling, Zhao Shunan, Deng Yong, Xu Weidong, Wang Zonghan, Wang Wenjun, Lv Ruiling, Liu Donghong.  (2023)  Antibacterial activity and mechanisms of α-terpineol against foodborne pathogenic bacteria.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  (1-13).  [PMID:37682300] [10.1007/s00253-023-12737-4]
2. Hua-Hua Liu, Yang Xu, Cao-Jie Li, Shu-Jung Hsu, Xia-Hui Lin, Rui Zhang, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Xin-Rong Yang, Zheng-Gang Ren, Rong-Xin Chen.  (2022)  An SCD1-dependent mechanoresponsive pathway promotes HCC invasion and metastasis through lipid metabolic reprogramming.  MOLECULAR THERAPY,  30  (2554-2567).  [PMID:35358687] [10.1016/j.ymthe.2022.03.015]
3. Chen Yingxian, Zhao Qian, Han Junhua, Lan Xinmiao, Che Jing, Chen Meiwan, Liang Xing-Jie, Ma Xiaowei.  (2022)  Dual Drug Loaded pH-sensitive Micelles for Efficient Bacterial Infection Treatment.  PHARMACEUTICAL RESEARCH,  39  (6): (1165-1180).  [PMID:35165820] [10.1007/s11095-022-03182-5]
4. Meng Zhao, Fangning Qu, Zhengjun Wu, Katsuyoshi Nishinari, Glyn O. Phillips, Yapeng Fang.  (2017)  Protection mechanism of alginate microcapsules with different mechanical strength for Lactobacillus plantarum ST-III.  FOOD HYDROCOLLOIDS,  66  (396).  [10.1016/j.foodhyd.2016.12.013]
5. Menghua Gao, Jiafeng Zhong, Xinxin Liu, Yanjun Zhao, Dingcheng Zhu, Xiaohuo Shi, Xuehan Xu, Qin Zhou, Wenjing Xuan, Yue Zhang, Yaofeng Zhou, Jianjun Cheng.  (2025)  Deciphering the Role of PEGylation on the Lipid Nanoparticle-Mediated mRNA Delivery to the Liver.  ACS Nano,  [PMID:39899798] [10.1021/acsnano.4c09399]
6. Xiaoyi Cheng, Ruiqi Peng, Mingxi Zou, Yan Chen, Wenkang Li, Zhongjiang Wang, Jing Xu, Zengwang Guo.  (2025)  Effect of phase transition of soy protein-chitosan complexes on liposomes stability: The perspective of membrane structure and inlaid stabilization mechanism.  FOOD CHEMISTRY,  480  (143911).  [PMID:40117822] [10.1016/j.foodchem.2025.143911]
7. Yongjie Zhu, Wanying Xu, Wenwen Chen, Bowen Li, Guoyu Li, Haoran Deng, Licong Zhang, Changxuan Shao, Anshan Shan.  (2025)  Self-assembling peptide with dual function of cell penetration and antibacterial as a nano weapon to combat intracellular bacteria.  Science Advances,  11  (6): (2025 Feb;11(6)).  [PMID:39908383] [10.1126/sciadv.ads3844]
8. Ye Zifan, Fu Lei, Li Shuangyu, Chen Ziying, Ouyang Jianhong, Shang Xinci, Liu Yanli, Gao Lianghui, Wang Yipeng.  (2024)  Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides.  Nature Communications,  15  (1): (1-26).  [PMID:39183339] [10.1038/s41467-024-51730-x]
9. Qianwei Qu, Xingyu Huang, Zhenxin Zhu, Jun Wang, Mengmeng Zhao, Wenqiang Cui, Yadan Zheng, Yanyan Liu, Xueying Chen, Zhiyun Zhang, Na Dong, Chunliu Dong, Yanhua Li.  (2025)  Targeting membrane integrity and imidazoleglycerol-phosphate dehydratase: Sanguinarine multifaceted approach against Staphylococcus aureus biofilms.  PHYTOMEDICINE,  138  (156428).  [PMID:39879703] [10.1016/j.phymed.2025.156428]

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