| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| J611280-5mg |
5mg |
期货  |
| |
| J611280-25mg |
25mg |
期货 |
|
| 英文别名 | JPC-3210 | 4-tert-butyl-2-[(tert-butylamino)methyl]-6-[5-fluoro-6-(trifluoromethyl)pyridin-3-yl]phenol | MMV646 | SCHEMBL15674459 | GTPL10395 | DYULPLHABFGTOQ-UHFFFAOYSA-N | MMV892646 | DB15609 | SB19203 | 1609655-35-7 |
|---|---|
| 规格或纯度 | Moligand™ |
| 英文名称 | JPC-3210 |
| IIUPAC Name | 4-tert-butyl-2-[(tert-butylamino)methyl]-6-[5-fluoro-6-(trifluoromethyl)pyridin-3-yl]phenol |
|---|---|
| INCHI | 1S/C21H26F4N2O/c1-19(2,3)14-7-13(11-27-20(4,5)6)17(28)15(9-14)12-8-16(22)18(26-10-12)21(23,24)25/h7-10,27-28H,11H2,1-6H3 |
| InChi Key | DYULPLHABFGTOQ-UHFFFAOYSA-N |
| Smiles | Oc1c(CNC(C)(C)C)cc(cc1c1cnc(c(c1)F)C(F)(F)F)C(C)(C)C |
| Isomeric SMILES | CC(C)(C)C1=CC(=C(C(=C1)C2=CC(=C(N=C2)C(F)(F)F)F)O)CNC(C)(C)C |
| PubChem CID | 90122671 |
| 1. Chavchich M, Birrell GW, Ager AL, MacKenzie DO, Heffernan GD, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. (2016) Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.. Antimicrob Agents Chemother, 60 (5): (3115-8). [PMID:26856849] |
| 2. Birrell GW, Heffernan GD, Schiehser GA, Anderson J, Ager AL, Morales P, MacKenzie D, van Breda K, Chavchich M, Jacobus LR et al.. (2018) Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.. Antimicrob Agents Chemother, 62 (4): [PMID:29311093] |
| 3. Birrell GW, Challis MP, De Paoli A, Anderson D, Devine SM, Heffernan GD, Jacobus DP, Edstein MD, Siddiqui G, Creek DJ. (2020) Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum.. Mol Cell Proteomics, 19 (2): (308-325). [PMID:31836637] |
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