IHVR-19029

COA

级别和纯度:

≥96%

CAS编号: 1447464-73-4
分子式: C₂₃H₄₅N₃O₅
分子量: 443.62

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货号 (SKU)	包装规格	是否现货
I650185-5mg	5mg	期货
I650185-10mg	10mg	期货
I650185-50mg	50mg	期货
I650185-100mg	100mg	期货

查看相关系列

Glucose Metabolism (3713) Glucosidase (71) Metabolic Enzyme/Protease (4889) Virus (3767)

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基本描述

规格或纯度	≥96%
英文名称	IHVR-19029
生化机理	IHVR-19029 是一种强效的内质网（ER）α-葡萄糖苷酶 I 和 II 抑制剂，ER a-葡萄糖苷酶 I 的 IC 50 为 0.48 μM。
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
产品介绍	IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC 50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir improves the antiviral efficacy. In Vitro IHVR-19029 efficiently inhibits Bovine viral diarrhea virus (BVDV), Tacaribe virus (TCRV) and Dengue virus (DENV) with EC 50 s of 0.25, 0.74, and 1.25 μM, respectively.\nThe combination of IHVR-19029 and Favipiravir synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo IHVR-19029 (25-75 mg/kg; I.p.; twice daily for 10 days) inhibits EBOV and MARV infection in mice. IHVR-19029 (5 mg/kg; i.v.) has AUC, C 0 , T 1/2 , CL and V d values of 1383 μgh/mL, 1.79 μg/mL, 1.2 hours, 3.49 L/h/kg, and 3.0 L/kg, respectively. IHVR-19029 (75/5/5 mg/kg; p.o./i.m./i.p.) has AUC values of 945/1839/983 μgh/mL, C max values of 0.26/1.23/1.33 μg/ml, T max values of 2.1/0.1/0.17 hours, and F values of 4.6/71/133%, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c mice (12 week 233 of age) (MARV infection)Dosage: 25, 75 mg/kg Administration: I.p.; twice daily, until 10 days Result: Significant protection of Marburg virus (MARV) induced death were observed. Animal Model: C57B1/6 mice (8–12 week of age) (EBOV infection)Dosage: 25, 75 mg/kg Administration: I.p.; twice daily for 10 days Result: Significant survival were observed. Form:Solid
纯度	≥96%

化学和物理性质

溶解性	DMSO : 100 mg/mL (225.42 mM; Need ultrasonic)

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

IHVR-19029

库存信息

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基本描述

名称和识别符

化学和物理性质

质检证书（CoA,COO,BSE/TSE 和分析图谱)

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器