基本描述

英文别名	CCG-36081 \| 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione \| 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone \| hypericin \| DTXSID40203270 \| Hypericin & Visible light \| LMPK13040001 \| NCI60_006799 \| M01850 \| MFCD0001668
规格或纯度	Moligand™, ≥96%
英文名称	Hypericin
生化机理	选择性PKC抑制剂（IC 50 = 3.3μM）。抗病毒剂。强大的酪氨酸激酶抑制剂（IC 50 = 7.5μM）。强大的CKII抑制剂（IC 50 = 6 nM）。使包括HIV在内的包膜病毒失活。促进VEGF和TGF-β的产生。
应用	金丝桃素是贯叶连翘光反应的色素，在590-600纳米被光激活，呈现高度毒性（Amax = 592纳米）。在体外和体内它均诱导癌细胞凋亡，是一种强力的抗病毒试剂。它激活化合物，抑制蛋白激酶C，不可逆转的损害sarco/内质网和其他细胞膜，降低细胞的pH值，抑制线粒体的功能。金丝桃素具有抗病毒、抗癌、抗抑郁等功能，近年来的研究表明还可高效作用于禽流感H5N1型病毒；金丝桃素具有光敏活性和光动作用；金丝桃素能抑制HIV及其它一些反转录病毒。
储存温度	2-8°C储存,避光
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	金丝桃素是贯叶连翘的主要活性成分。金丝桃素是贯叶连翘光反应的色素，在590-600纳米被光激活，呈现高度毒性（Amax = 592纳米）。在体外和体内它均诱导癌细胞凋亡，是一种强力的抗病毒试剂。它激活化合物，抑制蛋白激酶C，不可逆转的损害sarco/内质网和其他细胞膜，降低细胞的pH值，抑制线粒体的功能。金丝桃素具有抗病毒、抗癌、抗抑郁等功能，近年来的研究表明还可高效作用于禽流感H5N1型病毒；金丝桃素具有光敏活性和光动作用；金丝桃素能抑制HIV及其它一些反转录病毒。
纯度	≥96%

名称和识别符

PubChem SID	504750693
EC号	208-941-0
IIUPAC Name	9,11,13,16,18,20-hexahydroxy-5,24-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(26),2,4(25),5,8,10,12,14(28),15(27),16,18,20,23-tridecaene-7,22-dione
INCHI	1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,33-38H,1-2H3
InChi Key	YDOIFHVUBCIUHF-UHFFFAOYSA-N
Smiles	CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O
Isomeric SMILES	CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O
关联CAS	1372719-41-9,548-04-9
NSC Number	407313
MeSH Entry Terms	1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione;hipericin;hypericin;hypericum red;mono-(123I)iodohypericin;SGX-301;SGX301
分子量	504.44
Beilstein号	1917913
Reaxy-Rn	35831525
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35831525&ln=

化学和物理性质

密度	1.915
敏感性	对光敏感
分子量	504.400 g/mol
XLogP3	5.700
氢键供体数Hydrogen Bond Donor Count	6
氢键受体数Hydrogen Bond Acceptor Count	8
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	504.085 Da
单同位素质量Monoisotopic Mass	504.085 Da
拓扑极表面积Topological Polar Surface Area	156.000 Å²
重原子数Heavy Atom Count	38
形式电荷Formal Charge	0
复杂度Complexity	1090.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS06, GHS07
信号词	危险
危险声明	H301: 吞咽会中毒 H302: 吞食有害 H317: 可能引起皮肤过敏反应
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany	3

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批号(Lot Number)	证书类型	货号
B2527125	分析证书	H110188
H2427432	分析证书	H110188
H2427439	分析证书	H110188
A2402115	分析证书	H110188
G2215445	分析证书	H110188
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G2215447	分析证书	H110188

此产品的引用文献

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引用文献

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溶液计算器

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计算溶液所需的质量、体积或浓度。

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稀释计算器

计算配制储备溶液所需的稀释度。

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

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货号 (SKU)	包装规格	是否现货
H110188-5mg	5mg	现货
H110188-25mg	25mg	现货
H110188-50mg	50mg	现货
H110188-100mg	100mg	现货

金丝桃素

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基本描述

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化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器