| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G650882-1mg |
1mg |
期货  |
|
| 别名 | 吉沃西兰 |
|---|---|
| 规格或纯度 | ≥97% |
| 英文名称 | Givosiran |
| 生化机理 | Givosiran（ALN-AS1）是一种靶向肝脏氨基乙酰丙酸合成酶 1（ALAS1）信使 RNA 的小干扰 RNA。Givosiran 可下调 ALAS1 mRNA，防止神经毒性δ-氨基乙酰丙酸和卟啉原水平的积累。Givosiran c |
| 储存温度 | 避光,-20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria. In Vitro Givosiran is conjugated to a trivalent N-acetylgalactosamine ligand, which binds specifically to the asialoglycoprotein receptor, enabling targeted delivery to hepatocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| 纯度 | ≥97% |
| Smiles | [Givosiran] |
|---|---|
| 分子量 | 16300.6 (AS: 7563.9 + SS: 8736.7) |
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