| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G649474-5mg |
5mg |
期货  |
| |
| G649474-10mg |
10mg |
期货 |
|
| 规格或纯度 | ≥99% |
|---|---|
| 英文名称 | (R,R)-GSK321 |
| 生化机理 | (R,R)-GSK321 是一种野生型异柠檬酸脱氢酶 1（WT IDH1）抑制剂，IC 50 值为 120 nM。(R,R)-GSK321作为一种突变型 R132H IDH1 抑制剂，是 GSK321 的异构体，具有一定的野生型交叉反应活性。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
(R,R)-GSK321 is a wild-type isocitrate dehydrogenase 1 ( WT IDH1 ) inhibitor with an IC 50 value of 120 nM. (R,R)-GSK321 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity In Vitro (R,R)-GSK321 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IDH1 |
| 纯度 | ≥99% |
| 分子量 | 501.55 |
|---|
| 溶解性 | DMSO : 250 mg/mL (498.45 mM; Need ultrasonic) |
|---|
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