| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G408589-1ml |
1ml |
现货  |
|
| 别名 | 盐酸胍 |
|---|---|
| 英文别名 | Aminoformamidine HCl | Guanidine, hydrochloride (1:1) |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Guanidine HCl |
| 生化机理 | 盐酸胍（氨基甲脒）是由胍氧化形成的强碱性结晶化合物，是蛋白质代谢的正常产物，也是一种蛋白质变性剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
易溶于水和乙醇，水溶液呈中性。有毒，半数致死量(小鼠，腹腔)500mg/kg。有刺激性。 检定金、铱、锇、铂和钌。变性,RNA分离。 强离液剂，用以变性和复性蛋白质。这种强劲的变性剂可以溶解不溶或变性的蛋白，如包涵体。这被用来作为复性到蛋白质或酶复性到活性状态的第一步。尿素和二硫苏糖醇（DTT）可能也是必要的。 Information Guanidine HCl (Aminoformamidine), the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant. Guanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state. Guanidine HCl is 2.8 times more effective than urea in unfolding ribonuclease but only 1.7 times more effective for lysozyme. △GH2Oapp. values of Guanidine HCl are 9.7 Cal/mole for ribonuclease at pH 6.6, 6.1 for lysozyme at pH 2.9, 8.3 for α-chymotrypsin at pH 4.3, and 11.7 for β-lactoglobulin at pH 3.2. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase. In vivo
cell lines：HT29-S-B6 colon cell Concentrations： Incubation Time： Powder Purity:≥100% |
| EC号 | 200-002-3 |
|---|---|
| Isomeric SMILES | C(=N)(N)N.Cl |
| 分子量 | 95.53 |
| Beilstein号 | 3591990 |
| Reaxy-Rn | 3591990 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3591990&ln= |
| 熔点 | 178-185°C |
|---|
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H302: 吞食有害 |
| 预防措施声明 |
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 |
| WGK Germany | 1 |
| RTECS | MF4300000 |
| Merck Index | 4562 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
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