按主题分类的文章 "Fluorinated block"

1. Synthesis Strategy of Pentafluorothio Group - Synthesis of Aliphatic Compounds Containing SF₅
   发布于 2025年7月29日

   15
   The pentafluorosulfanyl (SF₅) group, as a unique fluorine-containing functional group, has demonstrated broad application prospects in medicinal chemistry, materials science, and other fields due to its excellent chemical stability, high electronegativity, and lipophilicity. In recent years, ...
2. Synthesis Strategy of Pentafluorothio Group-Synthesis of SF₅Cl
   发布于 2025年7月29日

   4
   Pentafluorosulfanyl chloride (SF₅Cl), a pivotal reagent for direct pentafluorosulfanylation, has seen remarkable advancements in synthesis and handling safety. Key developments include
3. Synthesis Strategy of Pentafluorothio Group - Synthesis of Aromatic Compounds Containing SF₅
   发布于 2025年7月29日

   14
   In 2015, the Dolbier group reported a method where phenylacetylene is used as the substrate, reacting with SF₅Cl under the catalysis of triethylborane (BEt₃) to generate a chlorinated pentafluorosulfanylated intermediate (189).
4. Fluoroalkylation: Expansion of Togni Reagents
   发布于 2023年1月31日

   10
   The introduction of highly fluorinated groups in drug and pesticide candidate compounds is a powerful strategy to modulate their properties. The introduction of fluorinated side chains can modulate acid-base and lipophilicity, impart a dipole moment, lock confirmation, and mitigate undesirable ...