按主题分类的文章 "Building Blocks"

1. 3-Mercaptopropionic acid, 3-MPA
   发布于 2025年2月6日

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   3-Mercaptopropionic acid, 3-MPA
2. Synthesis and Metabolism of Glutamate and GABA: Core Mechanisms of Neurotransmitters
   发布于 2024年9月9日

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   Glutamate and γ-aminobutyric acid (GABA) are two of the most important neurotransmitters in the brain. Glutamate acts as the primary excitatory neurotransmitter, playing a crucial role in signal transmission within the central nervous system, while GABA serves as the main inhibitory ...
3. Boc resin lysis protocol
   发布于 2024年8月22日

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   In peptide synthesis, Boc protection groups are widely used to protect the amino terminus of amino acids to prevent unnecessary reactions during synthesis. After the peptide synthesis is complete, the peptide is released from the resin through the cleavage and deprotection steps, and these ...
4. CC-92480,Dalcetrapib,Tovorafenib and AZD4604
   发布于 2024年3月13日

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   The targets of action of drugs involve receptors, enzymes, ion channels, transporters, immune system, genes and many others. This paper describes four drugs involving enzyme targets of action and their synthetic routes.
5. GDC-1971: SHP2 Inhibitor Ushering in a New Era of Cancer Treatment
   发布于 2024年3月12日

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   In recent years, protein tyrosine phosphatase SHP2 has become a highly regarded research target in the field of oncology in mediating the RAS-driven MAPK signaling pathway. Its treatment methods are not limited to single drug use, but also can work together with KRAS inhibitors, showing good ...
6. ROS1 Fusion Inhibitor NVL-520 with MGAT2 Inhibitor BMS-963272
   发布于 2024年3月7日

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   ROS1 Fusion Inhibitor NVL-520 with MGAT2 Inhibitor BMS-963272
7. The process path of EBL-3183: from indole to preclinical inhibitor
   发布于 2024年3月1日

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   Metallo-β-lactamases (MBLs) are regarded as major determinants of carbapenem antibiotic resistance. Therefore, the search for new MBL inhibitors has become an urgent task at present. Recently, Prof. Andrei Baran and his team published an article in Org. Process Res. Dev, detailing the synthetic ...
8. Explore the Industrialization Process of SOS1 Inhibitor MRTX0902
   发布于 2024年2月27日

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   MRTX0902 is a highly effective SOS1:KRAS complex inhibitor that exhibits excellent brain penetration, high oral bioavailability, and strong selectivity. When combined with MRTX849 (1,2)-adagrasib (KRAZATI), it can significantly enhance its anti-tumor activity.
9. IACS-52825: A Potent and Selective DLK Inhibitor
   发布于 2024年2月22日

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   Chemotherapy-induced peripheral neuropathy (CIPN) is a serious problem in current tumor therapy. A team of researchers at MD Anderson Cancer Center published a study in the Journal of Medicinal Chemistry on the DLK inhibitor IACS-52825, which showed that the drug significantly ameliorated ...
10. Cyclic isomers--Azabicyclic molecular building blocks to aid drug design
    发布于 2024年2月22日

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    Recently, Ukrainian scientists reported a breakthrough research result in the journal Angewandte Chemie International Edition.They synthesized a new ring isomer, 3-azabicyclo[3.1.1]heptanes(aza-BCHP for short), by the reduction of spiroepoxetane, and Aladdin Scientific is available as a related ...