按主题分类的文章 "drug target ligand"

1. GDC-1971: SHP2 Inhibitor Ushering in a New Era of Cancer Treatment
   发布于 2024年3月12日

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   In recent years, protein tyrosine phosphatase SHP2 has become a highly regarded research target in the field of oncology in mediating the RAS-driven MAPK signaling pathway. Its treatment methods are not limited to single drug use, but also can work together with KRAS inhibitors, showing good ...
2. Explore the Industrialization Process of SOS1 Inhibitor MRTX0902
   发布于 2024年2月27日

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   MRTX0902 is a highly effective SOS1:KRAS complex inhibitor that exhibits excellent brain penetration, high oral bioavailability, and strong selectivity. When combined with MRTX849 (1,2)-adagrasib (KRAZATI), it can significantly enhance its anti-tumor activity.
3. D-DTTA Salts of Azaindole Chiral Amines: New Options for Chemical Splitting
   发布于 2024年2月22日

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   In the process of developing new drugs, chiral dihydroazaindolecarboxylic acid (R)-1 is in great demand as a key starting material for the synthesis of active pharmaceutical ingredients (APIs). However, the traditional synthesis method, chiral supercritical fluid chromatographic separation, is ...