按主题分类的文章 "Inhibitors"

1. PARP inhibitors
   发布于 2025年9月19日

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   Poly (ADP-ribose) polymerase (PARP) inhibitors represent a class of therapeutic agents employed in the management of cancer, neurodegenerative disorders, and cardiovascular diseases.
2. Pim Kinase Inhibitors
   发布于 2025年9月18日

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   Pim kinases are a family of serine/threonine kinases that play critical roles in regulating cell cycle progression and programmed cell death (apoptosis). Two major isoforms have been identified—Pim-1 and Pim-2—both of which are expressed in lymphoid cells and are essential for cytokine-driven ...
3. Temozolomide and MGMT Inhibitors
   发布于 2025年9月18日

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   Temozolomide is an alkylating chemotherapeutic agent widely used in the treatment of several cancers. Like other alkylating agents, it exerts its cytotoxic effect by transferring alkyl groups to DNA, primarily at the N7 and O6 positions of guanine and the N3 position of adenine.
4. VEGFR Inhibitors
   发布于 2025年9月18日

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   Vascular endothelial growth factor receptor (VEGFR) inhibitors are a class of compounds that block signaling through VEGF receptor tyrosine kinases. VEGFR plays a central role in angiogenesis, the formation of new blood vessels, which is a critical process in tumor growth and progression.
5. Lysate would like to ask what PMSF does with Na3VO4?
   发布于 2024年8月27日

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   Lysate would like to ask what PMSF does with Na3VO4?
6. GDC-1971: SHP2 Inhibitor Ushering in a New Era of Cancer Treatment
   发布于 2024年3月12日

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   In recent years, protein tyrosine phosphatase SHP2 has become a highly regarded research target in the field of oncology in mediating the RAS-driven MAPK signaling pathway. Its treatment methods are not limited to single drug use, but also can work together with KRAS inhibitors, showing good ...
7. The process path of EBL-3183: from indole to preclinical inhibitor
   发布于 2024年3月1日

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   Metallo-β-lactamases (MBLs) are regarded as major determinants of carbapenem antibiotic resistance. Therefore, the search for new MBL inhibitors has become an urgent task at present. Recently, Prof. Andrei Baran and his team published an article in Org. Process Res. Dev, detailing the synthetic ...
8. Innovations in the design of stereospecific drug molecular structures: Spirocyclic Scaffolds
   发布于 2024年1月18日

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   Spirocyclic compounds are not new as an important area of drug research. In recent years, the demand for compounds with high stereospecificity and spatial structure has been increasing, and the introduction of spirocyclic scaffolds has become an innovative strategy in drug design. Spirocyclic ...