Resveratrol

Resveratrol is a stilbene-type phytoalexin found in the skins and seeds of grapes, as well as in various other plants such as peanuts, soybeans, and mulberries. Similar to other phytoalexins, resveratrol exhibits diverse bioactivities, including antioxidant, anticancer, neuroprotective, and cardioprotective effects.

Figure 1. Chemical Structure of Resveratrol

Main Functions:

Anti-aging: Activates Sirtuin-1, a mechanism associated with its potential anti-aging and metabolic regulatory effects.

Antioxidant: Acts as a potent antioxidant that inhibits low-density lipoprotein (LDL) oxidation and alleviates oxidative stress in vitro.

Anticancer: Demonstrates broad chemopreventive and chemotherapeutic potential in various cell and animal models; also inhibits cyclooxygenase (COX) and peroxidase activities, both of which are closely linked to cancer progression.

Metabolism-promoting: Reduces hepatic fat content and cholesterol levels, and inhibits platelet aggregation.

In addition, the resveratrol derivative pterostilbene, a fully methylated analog of resveratrol, has shown greater efficacy than resveratrol in inhibiting cell and tumor growth in colorectal and prostate cancer models. Another derivative, triacetylresveratrol, is a prodrug of resveratrol with higher bioavailability and similar potential anticancer activity to the parent compound.

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References

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2. Prasad K. Int J Angiol. 2012 Mar;21(1):7-18.

3. Yin HT, Tian QZ, Guan L, et al. Asian Pac J Cancer Prev. 2013;14(3):1703-6.

4. Pan MH, Gao JH, Lai CS, et al. Mol Carcinog. 2008 Mar;47(3):184-96.

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