Diallyl Trisulfide

发布于 2025年8月27日更新时间 2025年8月27日

Diallyl trisulfide (DATS) is an organosulfur compound derived from garlic and other Allium species. It is a decomposition product of allicin formed when garlic is crushed.

Figure 1. Chemical Structure of Diallyl Trisulfide

1. Bioactivity of Diallyl Trisulfide (DATS)

DATS exhibits antibacterial activity, inhibiting the growth of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.

In diabetic animal models, DATS improves cardiac function by enhancing the PI3K–Akt signaling pathway, inhibiting death receptor- and mitochondria-dependent apoptosis, thereby alleviating diabetic cardiomyopathy.

DATS possesses anticancer activity, with antioxidant properties potentially contributing to its chemotherapeutic effects. In leukemia cells, DATS promotes ROS generation, activates caspases, induces apoptosis, and suppresses proliferation.

DATS also exhibits chemopreventive effects. In a skin tumor carcinogenesis animal model, DATS inhibits TPA-induced papilloma formation and the increase in papilloma number.

2.Related Products

Name	ID	Specification/Purity
Diallyl trisulfide	D302734	≥65%
Allicin	A303933	≥80%, mixture
Allicin	A424615	10mM in DMSO
Diallyl Sulfide	D101110	≥98%
L-Deoxyalliin	S422599	10mM in Water
L-Deoxyalliin	I137523	≥98%(T)
L-Alliin	L276129	≥98%
(+)-Alliin	A424735	10mM in DMSO
(+)-Alliin	A110692	Analytical Standard, ≥98%
(+)-Alliin	A110693	≥90%

References

1. Casella S, Leonardi M, Melai B, et al. Phytother Res. 2013 Mar;27(3):380-3.

2. Huang YT, Yao CH, Way CL, et al. J Appl Physiol (1985). 2013 Feb;114(3):402-10.

3. Choi YH, Park HS. J Biomed Sci. 2012 May 11;19:50.

4. Kelkel M, Cerella C, Mack F, et al. Carcinogenesis. 2012 Nov;33(11):2162-71.v

Aladdin: https://www.aladdinsci.com/

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