Curcumin

Curcumin s a natural polyphenolic compound derived from turmeric, a member of the ginger family that has long been used as a food preservative and textile dye. Along with curcumin, the two other major curcuminoids found in turmeric are Demethoxycurcumin (D117978 analytical standard ≥98%，D299451 ≥95% ) and Bisdemethoxycurcumin (B117979 analytical standard ≥98%，B131602 ≥98%(HPLC) ). These compounds demonstrate diverse biological activities, including antioxidative, anticancer, anti-inflammatory, and antimicrobial effects.

Curcumin has been reported to exhibit antiviral properties, notably inhibiting HIV-1 integrase activity in vitro. Since HIV integrase is essential for viral replication, curcumin also reduces HIV-1 propagation.

In addition, curcumin shows neuroprotective potential. In amyloid-β–infused animal models, it prevents the formation of soluble oligomers. Amyloid-β (Aβ) aggregation into plaques is a central feature of Alzheimer’s disease. In vivo, curcumin accumulates at amyloid deposits, where it both blocks new plaque formation and facilitates clearance of existing aggregates.

Curcumin also influences cancer biology. In breast cancer cell models, it reduces metastatic capacity by inhibiting transcription of CXCL1 and CXCL2, thereby silencing CXCR4 and other metastasis-associated proteins. Conversely, other studies suggest curcumin may promote cancer under specific conditions. For example, in lung models, curcumin accelerated the progression of benign hyperplasias into adenomas and carcinomas. When compared with BHT, a known carcinogen, curcumin displayed a similar ability to drive tumor progression—an effect potentially linked to modulation of ROS levels and oxidative stress in lung tissue. Moreover, curcumin disrupts the natural conformation of tumor suppressor p53, reducing its ability to bind DNA and trigger cell cycle arrest.

Beyond natural curcuminoids, synthetic derivatives such as 3,4-Difluorobenzocurcumin also shows special properties. Early research suggests this compound has improved pharmacokinetic properties and stronger biological activity compared to curcumin, making it a promising candidate for diverse biomedical applications.

Available curcuminoids From Aladdin:

C140600 Curcumin ≥65%

C463317 Curcumin ≥95%,≥75%(Curcumin) total curcumin content

C400222 Curcumin Natural extraction (isomer mixture)

C110685 Curcumin Analytical standard

C477437 Curcumin from Curcuma longa (Turmeric),powder

C395975 Curcumin solution 0.1% in 95% Ethanol

C400271 Curcumin from Synthetic ≥98%

C408195 Curcumin 10mM in DMSO

D275661 Dimethoxycurcumin ≥90%

References:

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4. Garcia-Alloze M, Borrelli A, Rozkalne A, et al. J Neurochem. 2007 Aug;102(4):1095-104.

5. Bachmeier B, Mohrenz I, Mirisola V, et al. Carcinogenesis. 2008 Apr;29(4):779-89.

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8. Ali S, Ahmad A, Banerjee S, et al. Cancer Res. 2010 May 1;70(9):3606-17.

Aladdin: https://www.aladdinsci.com/