Compounds found in Green Tea

Extracts derived from green tea leaves are rich in biologically active compounds with diverse therapeutic potential. Initially investigated for their antioxidant properties, these constituents have since demonstrated anticancer, antiviral, and anti-inflammatory activities in both experimental and preclinical models.

The principal bioactive agents in green tea are catechins, including Epigallocatechin Gallate (EGCG, Aladdin E107403 analytical standard, E107404 ≥98%, E409009 10mM in DMSO), Epigallocatechin (EGC, Aladdin E100889 analytical standard ≥98%, E427179 10mM in DMSO, E100888 ≥98%(HPLC)), Epicatechin Gallate (ECG, Aladdin E101658 analytical standard ≥98%, E101659 ≥98%, E421081 10mM in DMSO), and Epicatechin (Aladdin E130023 ≥97%, E432751 ≥90%, E107318 analytical standard ≥98%, E424244 10mM in DMSO ). These naturally occurring polyphenols exhibit strong chemopreventive and chemotherapeutic properties, suppressing cancer cell proliferation in a variety of in vitro systems. Mechanistically, catechins modulate critical pathways by influencing MAPK signaling, cyclin-dependent kinase (CDK) expression, topoisomerase I activity, and NF-κB activation.

Among them, EGCG is the most extensively studied, shown to inhibit receptor tyrosine kinases such as EGFR, IGF-1R, and VEGFR2. This results in apoptosis induction and growth suppression in colorectal carcinoma and hepatocellular carcinoma cell lines.

Beyond oncology, green tea catechins also demonstrate antiviral and anti-inflammatory benefits. Epicatechin, for example, has been reported to inhibit replication of the hepatitis C virus and to reduce expression of key inflammatory mediators, including COX-2, iNOS, TNF-α, and IL-1β. In erythrocyte models, catechins protect against oxidative stress by reducing malondialdehyde formation and preserving intracellular glutathione levels.

Green tea extract also provides other flavonoids and amino acids that contribute to its biological effects. Notable examples include:

• Quercetin (Q104838 ≥97%, Q118458 analytical standard ≥98%): In animal models of subarachnoid hemorrhage, quercetin improves neurological function, likely by enhancing antioxidant enzyme activity (superoxide dismutase and glutathione peroxidase) and lowering malondialdehyde accumulation.

• Myricetin (M111175 ≥97%, M111176 analytical standard ≥98%, M407976 10mM in DMSO ): Triggers reactive oxygen species (ROS)-mediated apoptosis in leukemia cells, underscoring its potential as an antitumor agent.

• L-Theanine (T106217 ≥99%, T106216 ≥98%, L423183 10mM in Water ): An amino acid unique to tea, shown to lower blood pressure in spontaneously hypertensive animal models, suggesting cardiovascular benefits.

In addition to purified catechins and flavonoids, Aladdin supplies mixtures such as Green Tea Polyphenols (T418534 TP98%, T426207 10mM in DMSO) and a high-purity Catechin (C114051 analytical standard ≥97%, C421835 10mM in DMSO ), offering versatile options for research and development applications.

References

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