Aggregation-Induced Emission (AIE)

Aggregation-Induced Emission (AIE) refers to the phenomenon where certain organic luminescent molecules (fluorescent dyes) exhibit enhanced light emission in the aggregated or solid-state compared to their solution state. This effect is contrary to the typical behavior of most organic compounds, which usually experience fluorescence quenching due to phenomena such as aggregation-caused quenching (ACQ) in the solid state. The primary cause of AIE is the restricted molecular motion in the aggregated state (reduced flexibility), which effectively suppresses non-radiative energy dissipation and improves fluorescence efficiency. Furthermore, fluorescence enhancement can also occur when molecular motion is restricted due to host–guest interactions or increased viscosity of the solution, a phenomenon rarely seen in conventional host–guest complexes.

Aggregation-Induced Emission Enhancement (AIEE) refers to the phenomenon in which certain organic luminescent molecules exhibit a higher photoluminescence efficiency in the aggregated state than in the solution state. Some luminescent molecules (such as diketopyrrolopyrrole and sulfonamide compounds) only show stronger emission when they enter the crystalline state, a phenomenon referred to as Crystallization-Induced Emission Enhancement (CIEE). Additionally, some luminescent materials (such as noble metal nanoclusters) also show higher photoluminescence efficiency in the aggregated state compared to when they are uniformly dispersed in solution, a phenomenon known as Aggregation-Induced Emission (AIE).

Aggregation-Induced Emission Polymers (AIE Polymers) are a class of fluorescent polymers capable of absorbing light at specific frequencies and re-emitting light. These polymers have significant applications in the field of biomaterials. Due to their excellent biocompatibility and fluorescence properties, they can assist researchers in locating and labeling proteins. Furthermore, polymers with AIE characteristics can reduce damage to healthy tissues in drug applications, offering potential biomedical value.

♦︎ Nucleic Acid Testing

♦︎ Cellular / Subcellular Organelle Fluorescent Probes

​

♦︎ Microbial Fluorescent Staining Reagents

♦︎ Fluorescent Nanoparticles

​

References

1.  Hong, Yuning; Lam, Jacky W. Y.; Tang, Ben Zhong (2011). "Aggregation-induced emission". Chemical Society Reviews. 40 (11): 5361–88. 

2.  Mei, Ju; Hong, Yuning; Lam, Jacky W. Y.; Qin, Anjun; Tang, Youhong; Tang, Ben Zhong (August 2014). "Aggregation-Induced Emission: The Whole Is More Brilliant than the Parts". Advanced Materials. 26 (31): 5429–5479. Bibcode:2014AdM....26.5429M. 

3.  Mei, Ju; Leung, Nelson L. C.; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Tang, Ben Zhong (22 October 2015). "Aggregation-Induced Emission: Together We Shine, United We Soar!". Chemical Reviews. 115 (21): 11718–11940. 

4.  Suzuki, Satoshi; Sasaki, Shunsuke; Sairi, Amir Sharidan; Iwai, Riki; Tang, Ben Zhong; Konishi, Gen-ichi (2020). "Principles of Aggregation-Induced Emission: Design of Deactivation Pathways for Advanced AIEgens and Applications". Angewandte Chemie International Edition. 59 (25): 9856–9867. 

5.  Strada, Rebecca; Dunlop, David; Vorba, Michal; Raj, Amar; Tütüncü, Büşra Buse; Myllyperkiö, Pasi; Slanina, Tomáš; Kumpulainen, Tatu; Sebej, Peter (2025). "Restricting Intramolecular Motion Converts Non-Fluorescent Semicroconaine Dyes into Turn-On Aggregation-Induced Emission Probes". Materials Chemistry Frontiers. 

6.  Moghadam, Fatemeh Mortazavi; Rahaie, Mahdi (May 2019). "A signal-on nanobiosensor for VEGF165 detection based on supraparticle copper nanoclusters formed on bivalent aptamer". Biosensors and Bioelectronics. 132: 186–195. 

7.  Mortazavi Moghadam, Fatemeh; Bigdeli, Mohammadreza; Tamayol, Ali; Shin, Su Ryon (October 2021). "TISS nanobiosensor for salivary cortisol measurement by aptamer Ag nanocluster SAIE supraparticle structure". Sensors and Actuators B: Chemical. 344: 130160. 

Aladdin: https://www.aladdinsci.com/