| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F648200-1mg |
1mg |
期货  |
|
| 别名 | 芬戈莫德-d4 |
|---|---|
| 规格或纯度 | ≥98% |
| 英文名称 | Fingolimod-d4 |
| 生化机理 | Fingolimod-d 4 是氘标记的芬戈莫德。芬戈莫德（FTY720 游离碱）是一种 1-磷酸鞘磷脂（S1P）拮抗剂，在 K562 和 NK 细胞中的 IC50 为 0.033 nM。芬戈莫德也是一种 pak1 激活剂，是一种免疫抑制剂。 |
| 储存温度 | 2-8°C储存,干燥 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Fingolimod-d 4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator , a immunosuppressant. In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| 纯度 | ≥98% |
| IIUPAC Name | 2-amino-1,1,3,3-tetradeuterio-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol |
|---|---|
| INCHI | 1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3/i15D2,16D2 |
| InChi Key | KKGQTZUTZRNORY-ONNKGWAKSA-N |
| Smiles | CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N |
| Isomeric SMILES | [2H]C([2H])(C(CCC1=CC=C(C=C1)CCCCCCCC)(C([2H])([2H])O)N)O |
| 分子量 | 311.5 |
| Reaxy-Rn | 7811195 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7811195&ln= |
| 分子量 | 311.500 g/mol |
|---|---|
| XLogP3 | 4.200 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 12 |
| 精确质量Exact Mass | 311.276 Da |
| 单同位素质量Monoisotopic Mass | 311.276 Da |
| 拓扑极表面积Topological Polar Surface Area | 66.500 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 258.000 |
| 同位素原子数Isotope Atom Count | 4 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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