| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E755856-200μg |
200μg |
期货  |
| |
| E755856-500μg |
500μg |
期货 |
|
| 产品名称 | 人表皮生长因子，不含动物成分 |
|---|---|
| 规格或纯度 | 重组, 用于细胞培养, ≥97%(SDS-PAGE), EGF, expressed in Escherichia coli |
| 生化机理 | 表皮生长因子（EGF）有助于诱导细胞生长、增殖和分化。它可参与肾脏中肾组织的修复。它可借助瞬时受体电位阳离子通道6（TRMP6）促进镁的重吸收。EGF已被发现可参与药物性肾镁丢失的病理生理过程。 |
| 产品介绍 |
人表皮生长因子，不含动物成分，已用于： 用作在LHC-8培养基中的补充剂对肝细胞系进行培养 胎牛血清中（FBS）-杜氏改良必需培养基（DMEM）/F12培养基中，以用于人类神经胶质瘤细胞的原代培养 用作正常成纤维细胞（NFs）条件培养基中的添加剂，以研究其对子宫内膜癌细胞（EC）迁移和侵袭的影响作为肿瘤球培养基的成分应用： 表皮生长因子（EGF）在Henle′s环和肾远曲小管中合成。它也在唾液腺和十二指肠中产生。表皮生长因子（EGF）是小的促有丝分裂多肽（∼6 6 kDa），存在于许多哺乳动物物种中，分布在许多组织和体液中。†人EGF与β-尿抑胃素相同，β-尿抑胃素是基于其胃酸分泌抑制能力而被识别和分离的多肽。† EGF是生长因子家族的成员，其特征在于存在6个保守的半胱氨酸基序，形成了三个二硫键。重组人EGF中3个链内二硫键的位置与小鼠EGF的位置相同。†EGF与牛痘病毒19 kDa蛋白中包含的序列同源，† 该病毒可能利用EGF受体进入细胞† EGF对多种表皮和上皮细胞具有促有丝分裂作用，包括成纤维细胞、神经胶质细胞、乳腺上皮细胞、血管和角膜内皮细胞、牛粒层细胞、兔软骨细胞、HeLa细胞和SV40-3T3细胞。† Epidermal Growth Factor (EGF) is a small mitogenic polypeptide (∼6 kDa), which is present in many mammalian species and is distributed throughout a wide number of tissues and body fluids.† Human EGF is identical to β-urogastrone, a polypeptide which was recognized and isolated on the basis of its ability to inhibit gastric acid secretion.† EGF is a member of a growth factor family, which is characterized by the presence of 6 conserved cysteine motifs that form three disulfide bonds. The location of 3 intrachain disulfide bonds in recombinant human EGF is identical to that of mouse EGF.† EGF is homologous to a sequence contained in a 19 kDa protein of vaccinia virus,† which appears to utilize the EGF receptor to gain entry into cell† EGF is mitogenic for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, and SV40-3T3 cells.† Epidermal growth factor (EGF) is synthesized in Henle′s loop and the distal convoluted tubule in the kidney. It is also produced in salivary glands and duodenum. Application:Epidermal Growth Factor, human, animal component free has been used:
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| 物理形态 | 固体 |
|---|---|
| 浓度 | EGF, expressed in Escherichia coli |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| CAS编号和信息 | 62253-63-8 |
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