Evogliptin tartrate

COA

级别和纯度:

≥99%

CAS编号: 1222102-51-3
分子式: C₂₃H₃₂F₃N₃O₉
分子量: 401.4215009
PubChem编号: 135395528

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货号 (SKU)	包装规格	是否现货
E646233-5mg	5mg	期货
E646233-10mg	10mg	期货
E646233-25mg	25mg	期货
E646233-50mg	50mg	期货
E646233-100mg	100mg	期货

查看相关系列

Amino Acid/Protein Metabolism (4559) Autophagy (2848) Dipeptidyl Peptidase (57) Metabolic Enzyme/Protease (4889)

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基本描述

别名	酒石酸依沃列汀
英文别名	(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one;(2R,3R)-2,3-dihydroxybutanedioic acid \| DA-1229 (tartrate) \| Evogliptin tartrate [WHO-DD] \| R14RT6A3LK \| Evogliptin (tartrate) \| 1222102-51-3 \| 2-Pip
规格或纯度	≥99%
英文名称	Evogliptin tartrate
生化机理	酒石酸埃沃格列汀（DA-1229）是一种口服活性 DPP4 抑制剂，在小鼠模型中具有显著和持续的降血糖作用。酒石酸埃沃格列汀还能通过诱导肝细胞自噬，抑制肝细胞中炎症和纤维化信号的产生。
储存温度	2-8°C储存,干燥
运输条件	冰袋运输
作用类型	抑制剂
产品介绍	Evogliptin (DA-1229) tartrate is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy . Evogliptin tartrate can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation In Vitro Evogliptin tartrate (2.49 mM; 12 h) efficiently inhibits mDPP4 (membrane DPP4) enzymatic activity in PWM-induced H9 Th1 cells. Evogliptin tartrate prevents inflammatory and fibrotic signaling through autophagy induction in primary hepatocytes of ATG7 f/f -Cre + mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: H9 Th1 cells (pokeweed mitogen (PWM)-induced) Concentration: 2.49 mM (1 µg/mL) Incubation Time: 12 h Result: Potently inhibited mDPP4 (membrane DPP4) activity in a dose-dependent manner but did not affect either the cytokine profile or cell viability in PWM-activated CD4 + CD26 + H9 Th1 cells. In Vivo Evogliptin tartrate (100, 300 mg/kg; in animal feedings; single daily for 10 weeks) exhibits antidiabetic effects on HFD/STZ mice and improves glucose intolerance and insulin resistance. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ICR mice (four-week-old; HFD/STZ mice model). Dosage: 100, 300 mg/kg Administration: In animal feedings; single daily for 10 weeks Result: Decreased the blood glucose level from the second weekand persisted through the 10-week treatment, when at 300 mg/kg. Significantly reduced HbA1c level when dosage at 300 mg/kg. Significantly decreased 6 h-fasted blood glucose levels in a dose-dependent manner. Form:Solid IC50& Target:DPP-4
纯度	≥99%

名称和识别符

IIUPAC Name	(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one;(2R,3R)-2,3-dihydroxybutanedioic acid
INCHI	1S/C19H26F3N3O3.C4H6O6/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20;5-1(3(7)8)2(6)4(9)10/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27);1-2,5-6H,(H,7,8)(H,9,10)/t12-,16-;1-,2-/m11/s1
InChi Key	RBBXDAJRSNHIJZ-DLDKMZOSSA-N
Smiles	CC(C)(C)OCC1C(=O)NCCN1C(=O)CC(CC2=CC(=C(C=C2F)F)F)N.C(C(C(=O)O)O)(C(=O)O)O
Isomeric SMILES	CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
PubChem CID	135395528
分子量	401.4215009

化学和物理性质

溶解性	DMSO : 100 mg/mL (181.32 mM; Need ultrasonic)

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