| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E408892-1ml |
1ml |
现货  |
|
| 英文别名 | MCI-186 | 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Edaravone |
| 生化机理 | 依达拉奉（MCI-186）是一种新型的强效自由基清除剂，已被临床用于减少缺血性中风后的神经元损伤。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information Edaravone (MCI-186) is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke. Edaravone exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Edaravone provides the desirable features of NOS: it increases eNOS (beneficial NOS for rescuing ischemic stroke) and decreases nNOS and iNOS (detrimental NOS). Edaravone, which inhibits oxidation and enhances NO production derived from increased eNOS expression, may improve and conserve cerebral blood flow without peroxynitrite generation during reperfusion. In vivo Edaravone significantly reduces the infarct volume and improves the neurological deficit scores at 24 hours after reperfusion in mice brain. Edaravone markedly suppresses the accumulation of HNE-modified protein and 8-OHdG at the penumbra area during the early period after reperfusion and reduces microglial activation, iNOS expression, and nitrotyrosine formation at the late period. Edaravone attenuates renal function and pathologic findings significantly in rat kidney. Edaravone significantly reduces the generation of free radicals in the tubular cells indicated by dichlorodihydrofluorescein. Edaravone-treated animals shows significantly improved neurological outcome. Edaravone-treatment provides a significant reduction in the number of TUNEL-positive apoptotic cells, a decrease in Bax immunoreactivity and an increase in Bcl-2 expression within the peri-infarct area. Edaravone shows an excellent neuroprotective effect against ischemia/reperfusion brain injury through a Bax/Bcl-2 dependent anti-apoptotic mechanism. cell lines：Bladder epithelial cell line T24, RT-4 transitional cell papilloma bladder cell line, 5637 primary carcinoma bladder cell line, HCT-116, MDAMB231, MCF7, HEK293, A549, SKOV3 and DU145 Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 1.3 |
|---|
| EC号 | 201-891-0 |
|---|---|
| Isomeric SMILES | CC1=NN(C(=O)C1)C2=CC=CC=C2 |
| 分子量 | 174.20 |
| Beilstein号 | 609575 |
| Reaxy-Rn | 609575 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=609575&ln= |
| 沸点 | 287 °C/265 mmHg |
|---|---|
| 熔点 | 128-131°C |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H412: 对水生生物有害并具有长期持续影响 H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害 H317: 可能引起皮肤过敏反应 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 1 |
| RTECS | UQ9625000 |
| Merck Index | 6713 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| 1. Kai Wang, Wentao Zhou, Xiangyu Jin, Xuwei Shang, Xiaomei Wu, Lijuan Wen, Sufen Li, Yiling Hong, Jia Ke, Yichong Xu, Hong Yuan, Fuqiang Hu. (2023) Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke. Nanoscale, 15 (27): (11625-11646). [PMID:37377137] [10.1039/D3NR01071F] |
| 2. Youzhi Wang, Huifang Wang, Guoqing Yang, Qingjing Hao, Kan Yang, Huizhen Shen, Yulong Wang, Jinxin Wang. (2023) Design and synthesis of a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 256 (115374). [PMID:37150057] [10.1016/j.ejmech.2023.115374] |
| 3. Shuming Chen, Jintao Wang, Ning Jiang, Zhenyu Wang, Ziqiang Chen, Chenyang He, Kai Fang, Jian Zhang, Long Yuan, Ye Li, Chuannan Li, Ping Chen, Yu Duan. (2023) Effect of Edaravone (An Antioxidant) on the Performance of Organic Perovskite Solar Cells. Physica Status Solidi-Rapid Research Letters, 17 (5): (2200428). [10.1002/pssr.202200428] |
| 4. You-Zhi Wang, Yu-Long Wang, Hao-Jie Che, Yi-He Jia, Hui-Fang Wang, Lin-Fei Zuo, Kan Yang, Ting-Ting Li, Jin-Xin Wang. (2023) Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L.. JOURNAL OF ETHNOPHARMACOLOGY, 304 (116020). [PMID:36529254] [10.1016/j.jep.2022.116020] |
| 5. Guo Shenglong, Lei Qi, Guo Hena, Yang Qian, Xue Yanli, Chen Ruili. (2023) Edaravone Attenuates Aβ 1-42-Induced Inflammatory Damage and Ferroptosis in HT22 Cells. NEUROCHEMICAL RESEARCH, 48 (2): (570-578). [PMID:36333599] [10.1007/s11064-022-03782-y] |
| 6. Zhang Sichen, Qian Chunguo, Li Hailing, Zhao Zhimin, Xian Jianchun, Yang Depo. (2023) Structure–activity relationship of a housefly neuroprotective dodecapeptide that activates the nuclear factor erythroid 2-related factor 2 pathway. Journal of Natural Medicines, 77 (1): (96-108). [PMID:36136205] [10.1007/s11418-022-01650-1] |
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| 9. Jie Cao, Ning Xiong, Yu Zhang, Yuwei Dai, Yuye Wang, Lingyu Lu, Lin Jiang. (2022) Using RSM for Optimum of Optimum Production of Peptides from Edible Bird’s Nest By-Product and Characterization of Its Antioxidant’s Properties. Foods, 11 (6): (859). [PMID:35327281] [10.3390/foods11060859] |
| 10. Yun Wang, Puling Li, Xue Zhang, Lingyun Li, Mengjiao Liu, Xiaoqing Li, Yejia Dai, Cun Zhang, Shaojing Li. (2021) Mitochondrial-Respiration-Improving Effects of Three Different Gardeniae Fructus Preparations and Their Components. ACS Omega, 6 (50): (34229–34241). [PMID:34963909] [10.1021/acsomega.1c03265] |
| 11. Jinguo Shi, Yang Wang, Jianwen Chen, Yaoqiang Lao, Ping Huang, Liping Liao, Caibao Jiang, Xinhua Li, Jin Wen, Shujia Zhou, Jingxia Zhang. (2021) Synthesis and biological evaluation of 1,2,4-oxadiazole core derivatives as potential neuroprotectants against acute ischemic stroke. NEUROCHEMISTRY INTERNATIONAL, 148 (105103). [PMID:34147514] [10.1016/j.neuint.2021.105103] |
| 12. Difan Zhang, Yi Feng, Hanbo Pan, Zhenquan Xuan, Sicheng Yan, Yuechun Mao, Xiao Xiao, Xinghan Huang, Hui Zhang, Fei Zhou, Bojun Chen, Xiaowei Chen, Hao Liu, Xiaojun Yan, Hongze Liang, Wei Cui. (2021) 9-Methylfascaplysin exerts anti-ischemic stroke neuroprotective effects via the inhibition of neuroinflammation and oxidative stress in rats. INTERNATIONAL IMMUNOPHARMACOLOGY, 97 (107656). [PMID:33895476] [10.1016/j.intimp.2021.107656] |
| 13. Zhou Yiying, Wu Xiang, Ye Luying, Bai Yujing, Zhang Hui, Xuan Zhenquan, Feng Yi, Zhang Panpan, Chen Yi, Yan Yushan, Zhu Binbin, Cui Wei. (2020) Edaravone at high concentrations attenuates cognitive dysfunctions induced by abdominal surgery under general anesthesia in aged mice. METABOLIC BRAIN DISEASE, 35 (2): (373-383). [PMID:31916204] [10.1007/s11011-019-00532-y] |
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| 17. Lei Liu, Zhifang Ma, Qiaoyi Han, Wei Meng, Haozheng Wang, Xinghua Guan, Qiang Shi. (2024) Myricetin Oligomer Triggers Multi-Receptor Mediated Penetration and Autophagic Restoration of Blood-Brain Barrier for Ischemic Stroke Treatment. ACS Nano, 18 (14): (9895-9916). [PMID:38533773] [10.1021/acsnano.3c09532] |
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