DMHCA

COA

级别和纯度:

≥99%

CAS编号: 79066-03-8
分子式: C₂₆H₄₃NO₂
分子量: 401.63

有货

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货号 (SKU)	包装规格	是否现货
D646577-5mg	5mg	期货
D646577-10mg	10mg	期货
D646577-25mg	25mg	期货
D646577-50mg	50mg	期货

查看相关系列

LXR (28) Metabolic Enzyme/Protease (4889) Vitamin D Related/Nuclear Receptor (908) 脂质代谢 (4331)

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基本描述

规格或纯度	≥99%
英文名称	DMHCA
生化机理	DMHCA 是一种强效的选择性 LXR 激动剂，能特异性地激活 LXR 途径的胆固醇外流臂，而不会刺激甘油三酯的合成。DMHCA 具有抗炎作用xa0 ，可用于胆固醇稳态研究d
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	激动剂
产品介绍	DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects and can be used for the research of cholesterol homeostasis diabetes In Vitro In ex vivo treatment of diabetic CD34 + cells, DMHCA (10 µM; 16-18 hours) restores the fluidity of the membranes to baseline nondiabetic levels. DMHCA restores the levels of BM-derived TNF-α and IL-3 to baseline and significantly reduces CCL-2 production by >50% in the BM supernatants and the systemic circulation compares to the control mice. DMHCA also increases the number of CACs in the BM and peripheral circulation and upregulates the egression of vascular reparative cells into the peripheral circulation. In the PAGA analysis, DMHCA treatment enhances the overall production and robustness of erythrocyte progenitors. DMHCA enhances flux down the erythrocyte progenitor lineage. It also DMHCA increase in erythrocyte progenitor density in BM cells. DMHCA not only expands the proportion of erythrocyte progenitors but also increases the expression of the hemoglobin beta adult chain (HBB-BT). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo DMHCA (oral administration; 6 months; chow 8mg/kg body weight /day) restores cholesterol homeostasis in diabetic retina. It significantly increases endogenous LXR ligands, desmosterol, and total oxysterols in the diabetic retina . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: LXR
纯度	≥99%

化学和物理性质

溶解性	DMSO : 7.69 mg/mL (19.15 mM; Need ultrasonic)

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DMHCA

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基本描述

名称和识别符

化学和物理性质

质检证书（CoA,COO,BSE/TSE 和分析图谱)

溶液计算器

摩尔浓度计算器

稀释计算器

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