| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D422882-1ml |
1ml |
现货  |
|
| 英文别名 | Dehydrostepholidine chloride | HY-N0592 | BDBM50300549 | AKOS037514619 | s3299 | AC-34618 | 9,10-Dimethoxy-5,6-dihydro-7lambda~5~-isoquino[3,2-a]isoquinoline-2,3-diol hydrochloride | 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol |
|---|---|
| 规格或纯度 | 2mM in DMSO |
| 英文名称 | Demethyleneberberine |
| 生化机理 | 去亚甲基小檗碱（DMB）是黄柏（CPC）的一种成分，可明显减轻体重下降，降低髓过氧化物酶（MPO）活性，同时显著减少白细胞介素（IL）-6 和肿瘤坏死因子-α（TNF-α）等促炎细胞因子的产生，并抑制 NF-κB 信号通路的激活。去亚甲基小檗碱（DMB）可通过激活 AMPK 通路改善非酒精性脂肪肝（NAFLD）。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishesmyeloperoxidase (MPO)activity, while significantly reduces the production of pro-inflammatory cytokines, such asinterleukin (IL)-6andtumor necrosis factor-α (TNF-α), and inhibits the activation ofNF-κBsignaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating Targets NF-κB ; MPO ; IL-6 ; TNF-α ; IL-1β 33791, |
| IIUPAC Name | 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol |
|---|---|
| INCHI | 1S/C19H17NO4/c1-23-18-4-3-11-7-15-13-9-17(22)16(21)8-12(13)5-6-20(15)10-14(11)19(18)24-2/h3-4,7-10,22H,5-6H2,1-2H3/p+1 |
| InChi Key | HVTCKKMWZDDWOY-UHFFFAOYSA-O |
| Smiles | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)O)OC |
| Isomeric SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)O)OC |
| 分子量 | 324.35 |
| Reaxy-Rn | 1554250 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1554250&ln= |
| 分子量 | 324.300 g/mol |
|---|---|
| XLogP3 | 3.100 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 324.124 Da |
| 单同位素质量Monoisotopic Mass | 324.124 Da |
| 拓扑极表面积Topological Polar Surface Area | 62.800 Ų |
| 重原子数Heavy Atom Count | 24 |
| 形式电荷Formal Charge | 1 |
| 复杂度Complexity | 447.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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