Cyclo(Arg-Gly-Asp-D-Phe-Cys)

1篇引用文献

COA

级别和纯度:

≥97%

CAS编号: 862772-11-0
分子式: C₂₄H₃₄N₈O₇S
分子量: 578.64
PubChem编号: 22446328

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货号 (SKU)	包装规格	是否现货
C651166-1mg	1mg	期货
C651166-5mg	5mg	期货
C651166-10mg	10mg	期货

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Cytoskeleton (497) Integrin (91)

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基本描述

别名	环(精氨酸-甘氨酸-天冬氨酸-D-苯丙氨酸-半胱氨酸)
规格或纯度	≥97%
英文名称	Cyclo(Arg-Gly-Asp-D-Phe-Cys)
生化机理	环（Arg-Gly-Asp-D-Phe-Cys）（Cyclo RGDfC）是一种环状 RGD 肽，与 αvβ3 具有高亲和力，能破坏细胞整合素的相互作用。Cyclo（Arg-Gly-Asp-D-Phe-Cys）可抑制胚胎干细胞（ESC）中多能标志物的表达，并抑制肿瘤细胞的生长。
储存温度	避光,充氩,干燥,-80℃储存
运输条件	超低温冰袋运输
产品介绍	Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3 , can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors In Vitro Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM; 24 h) down-regulates the transcription factors Oct 4, Sox 2 and Nanog of mESCs. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM) inhibits integrin gene expression mESC-col I (type I collagen) constructs. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM)-treated mESC leads to the formation of aggregates and detachment from the surface. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: MESCs Concentration: 0.5 mM Incubation Time: 24 h Result: Down-regulated Oct 4, Nanog, Sox 2 by 99%, 97.5%, and 90% respectively. Up-regulated Rex1 gene expression. In Vivo Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM, 24 h)-treated mESCs in the presence/absence of Leukemia inhibitory factor (LIF) (injected in both thighs) generated teratomas in severe combined immunodeficiency (SCID) mice, which indicates that the process of mESC tumor formation in vivo is dependent on integrin interaction . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:αvβ3
纯度	≥97%

名称和识别符

IIUPAC Name	2-[5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-8-(sulfanylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
INCHI	1S/C24H34N8O7S/c25-24(26)27-8-4-7-14-20(36)28-11-18(33)29-16(10-19(34)35)22(38)31-15(9-13-5-2-1-3-6-13)21(37)32-17(12-40)23(39)30-14/h1-3,5-6,14-17,40H,4,7-12H2,(H,28,36)(H,29,33)(H,30,39)(H,31,38)(H,32,37)(H,34,35)(H4,25,26,27)
InChi Key	WNYJVAMZRBTOPE-UHFFFAOYSA-N
Smiles	C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CS)CC2=CC=CC=C2)CC(=O)O
Isomeric SMILES	C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CS)CC2=CC=CC=C2)CC(=O)O
PubChem CID	22446328
MeSH Entry Terms	c(RGDfC);cyclo(Arg-Gly-Asp-Phe-Cys);cyclo(arginyl-glycyl-aspartyl-phenylalanyl-cysteinyl);cyclo(RGDfC);cyclo-(Arg-Gly-Asp-D-Phe-Cys)
分子量	578.64

化学和物理性质

溶解性	DMSO : 50 mg/mL (86.41 mM; Need ultrasonic)

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引用文献

1. Tiantian Zhang, Lu Zhang, Yue Shen, Haiyan Xiao, Zengsheng Han, Longgang Wang, Song Ni. (2024) Zwitterionic targeting nanodrugs prepared from poly(propyleneimine) dendrimers for enhanced anti-tumor therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 694 (134193). [10.1016/j.colsurfa.2024.134193]

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Cyclo(Arg-Gly-Asp-D-Phe-Cys)

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基本描述

名称和识别符

化学和物理性质

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

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