CDE-096

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货号 (SKU)	包装规格	是否现货
C649438-5mg	5mg	期货
C649438-10mg	10mg	期货
C649438-25mg	25mg	期货
C649438-50mg	50mg	期货

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基本描述

规格或纯度	≥98%
英文名称	CDE-096
生化机理	CDE-096 是 PAI-1 的强效抑制剂。CDE-096 以相似的效力阻止 PAI-1 使 tPA 和 uPA 失活（IC 50 =30 和 25 nM），并对糖基化的 PAI-1 以及来自多个物种的 PAI-1 有活性（IC 50 =19、22、25 nM）。
储存温度	2-8°C储存,避光,干燥
运输条件	冰袋运输
产品介绍	CDE-096 is a potent inhibitor of PAI-1. CDE-096 prevents PAI-1 from inactivating tPA and uPA with similar potency ( IC 50 =30 and 25 nM, respectively) and is active against glycosylated PAI-1 , as well as PAI-1 derived from several species (IC 50 =19, 22 and 18 nM for murine, rat, and Porcine PAI-1 , respectively). In Vitro CDE-096 is active against both free PAI-1 and vitronectin-bound PAI-1. CDE-096 binds to PAI-1 with nanomolar affinity and induces conformational changes that prevent binding to both proteases and vitronectin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
纯度	≥98%

名称和识别符

IIUPAC Name	[3-[[3-(trifluoromethyl)phenoxy]carbonylamino]-2-(3,4,5-trihydroxybenzoyl)oxypropyl] 3,4,5-trihydroxybenzoate
INCHI	1S/C25H20F3NO12/c26-25(27,28)13-2-1-3-14(8-13)41-24(38)29-9-15(40-23(37)12-6-18(32)21(35)19(33)7-12)10-39-22(36)11-4-16(30)20(34)17(31)5-11/h1-8,15,30-35H,9-10H2,(H,29,38)
InChi Key	OXWKLJPAKUDPJY-UHFFFAOYSA-N
Smiles	C1=CC(=CC(=C1)OC(=O)NCC(COC(=O)C2=CC(=C(C(=C2)O)O)O)OC(=O)C3=CC(=C(C(=C3)O)O)O)C(F)(F)F
Isomeric SMILES	C1=CC(=CC(=C1)OC(=O)NCC(COC(=O)C2=CC(=C(C(=C2)O)O)O)OC(=O)C3=CC(=C(C(=C3)O)O)O)C(F)(F)F
PubChem CID	59350299
分子量	583.42

化学和物理性质

溶解性	DMSO : 100 mg/mL (171.40 mM; Need ultrasonic)

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