Cadisegliatin

COA

级别和纯度:

≥99%

CAS编号: 859525-02-3
分子式: C₂₁H₃₃N₃O₄S₂
分子量: 455.63
PubChem编号: 54673176

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货号 (SKU)	包装规格	是否现货
C646700-5mg	5mg	期货
C646700-10mg	10mg	期货
C646700-25mg	25mg	期货
C646700-50mg	50mg	期货

查看相关系列

Glucokinase (19) Glucose Metabolism (3713) Metabolic Enzyme/Protease (4889)

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基本描述

别名	钙调素
规格或纯度	≥99%
英文名称	Cadisegliatin
生化机理	Cadisegliatin（TTP-399）是一种潜在的口服活性肝脏选择性葡萄糖激酶（GK）激活剂。Cadisegliatin 具有抗高血糖活性。Cadisegliatin 可用于 2 型糖尿病的研究。
储存温度	避光,-80℃储存
运输条件	超低温冰袋运输
作用类型	激活剂
产品介绍	Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes. In Vitro Cadisegliatin (TTP-399) increases glucose metabolism in rat hepatocytes, the EC 50 values of lactate and glycogen in 15 nM glucose are 2.39 μM and 2.64 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo TTP399 (200 mg/kg, per os, p.o.) has no effect on plasma glucose and insulin in fasted rats. TTP399 (75 or 150 mg/kg, per day, for 4 weeks) improves glucose homeostasis in ob/ob mouse model. TTP399 (50 mg/kg, per day, for 13 weeks) is effective in reducing plasma glucose during an oral glucose tolerance test (OGTT) in minipigs model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nondiabetic fasted ratsDosage: 200 mg/kg Administration: 200 mg/kg, per os (p.o.) Result: Did not change the insulin and glucose concentrations in plasma. Animal Model: ob/ob mouse modelDosage: 75 or 150 mg/kg Administration: 75 or 150 mg/kg, per day, for 4 weeks Result: Reduced the expression of HbA1c, blood glucose concentrations, lactate concentrations and liver glycogen depots. Improved the lipid profile, reduced plasma, liver TG concentrations and the weight gain at the highest dose. Animal Model: Gottingen minipigsDosage: 50 mg/kg Administration: 50 mg/kg, per day, for 13 weeks Result: Eliminated the blood glucose excursion in Minipigs. Form:Solid
纯度	≥99%

名称和识别符

分子类型	小分子
Isomeric SMILES	CCCOC1CCC(CC1)N(C2CCCCC2)C(=O)NC3=NC=C(S3)SCC(=O)O
PubChem CID	54673176
分子量	455.63

化学和物理性质

溶解性	DMSO : 125 mg/mL (274.35 mM; Need ultrasonic)

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