| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C130202-1mg |
1mg |
现货  |
|
| 别名 | 26,26,26,27,27,27-六氢胆甾醇-5-烯-3β,25-二醇 | 25-羟基胆碱-5-en-3-醇(d6) | 25-羟基胆固醇-d6 |
|---|---|
| 英文别名 | 25-hydroxycholesterol-d6 | 26,26,26,27,27,27-hexadeuterocholest-5-ene-3β,25-diol | 25-hydroxycholest-5-en-3-ol(d6) | 25-Hydroxy Cholesterol-26,26,26,27,27,27-d6 |
| 规格或纯度 | ≥99 atom% D |
| 英文名称 | cholest-5-ene-3β,25-diol-d6 |
| 生化机理 | 25-hydroxycholesterol is a liver X receptor ligand. This bioactive lipid regulates immune response and macrophages production from monocytes. 25-HC serves as an antiviral effector and may have therapeutic potential. It reduces cholesterol biosynthesis by inactivating sterol regulatory element binding protein and inhibits HMG-CoA reductase (HMGCR). 25-HC may play a protective role in myocardial ischemia-reperfusion injury by inhibiting apoptosis and regulating mitogen-activated protein kinase (MAPK) pathway. |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
application： 25-hydroxycholesterol-d6 has been used as an internal standard: in the quantification of 25-OHC in jejunum samples by liquid chromatography with tandem mass spectrometry (LC-MS-MS) in plasma samples by liquid chromatography-mass spectrometry analysis for calibration curve generation for plasma oxysterol quantification |
| 纯度 | ≥99 atom% D |
| IIUPAC Name | (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
|---|---|
| INCHI | 1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1/i2D3,3D3 |
| InChi Key | INBGSXNNRGWLJU-KHKDDIDZSA-N |
| Smiles | CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C |
| Isomeric SMILES | [2H]C([2H])([2H])C(CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)(C([2H])([2H])[2H])O |
| 关联CAS | 2140-46-7（unlabelled） |
| 分子量 | 408.69 |
| Reaxy-Rn | 2062312 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2062312&ln= |
| 溶解性 | Chloroform (Slightly), DMSO (Slightly) |
|---|---|
| 熔点 | >155°C (dec.) |
| 分子量 | 408.700 g/mol |
| XLogP3 | 6.800 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 408.387 Da |
| 单同位素质量Monoisotopic Mass | 408.387 Da |
| 拓扑极表面积Topological Polar Surface Area | 40.500 Ų |
| 重原子数Heavy Atom Count | 29 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 636.000 |
| 同位素原子数Isotope Atom Count | 6 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 8 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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