基本描述

别名	盐酸黄连素
英文别名	MFCD00149997 \| Natural Yellow 18 \| AC-4573 \| 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride;hydrate \| Kyoberin (TN) \| FT-0631162 \| Berberinium chloride hydrate \| BCP28194 \| SCHEM
规格或纯度	≥95%
英文名称	Berberine Chloride Hydrate
生化机理	一种具有弱抗生素特性的生物碱。MDR 外排泵的底物。MDR 抑制剂 5′-甲氧基hydnocarpin（5′-MHC）可增强小檗碱的抗菌活性。小檗碱能上调肝癌细胞中 Pgp 的表达。使用小檗碱治疗可能会减少化疗药物的蓄积。
储存温度	充氩
运输条件	常规运输
产品介绍	一种生物碱，CAS号为633-65-8的为无水物 Fluorescent stain for heparin in mast cells
纯度	≥95%

名称和识别符

PubChem SID	504757401
EC号	211-195-9
IIUPAC Name	16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride;hydrate
INCHI	1S/C20H18NO4.ClH.H2O/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;;/h3-4,7-10H,5-6,11H2,1-2H3;1H;1H2/q+1;;/p-1
InChi Key	BPNJXFPOPCFZOC-UHFFFAOYSA-M
Smiles	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.O.[Cl-]
Isomeric SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.O.[Cl-]
关联CAS	2086-83-1;633-65-8;68030-18-2
分子量	371.81
Beilstein号	3836585
Reaxy-Rn	14849287
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14849287&ln=

化学和物理性质

溶解性	Soluble in water
密度	0.9879
敏感性	对湿度、光线敏感
熔点	200°C
分子量	389.800 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	389.103 Da
单同位素质量Monoisotopic Mass	389.103 Da
拓扑极表面积Topological Polar Surface Area	41.800 Å²
重原子数Heavy Atom Count	27
形式电荷Formal Charge	0
复杂度Complexity	488.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	3

安全和危险性（GHS）

WGK Germany	2
Merck Index	1154
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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找到3个结果

批号(Lot Number)	证书类型	货号
H2211109	分析证书	B489860
H2211138	分析证书	B489860
F2302927	分析证书	B489860

此产品的引用文献

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引用文献

1. Lijuan Xu, Xinzhong Hu, Liang Zou, Tian Ren. (2024) Preparation of photosensitive antibacterial nanocomposite film and its preservation effect on pork loin. LWT-FOOD SCIENCE AND TECHNOLOGY, 191 (115586). [10.1016/j.lwt.2023.115586]
2. Li Chen, Meng Tian, Jing Yang, Zhenxu Wu. (2023) Berberine-Encapsulated Poly(lactic-co-glycolic acid)–Hydroxyapatite (PLGA/HA) Microspheres Synergistically Promote Bone Regeneration with DOPA-IGF-1 via the IGF-1R/PI3K/AKT/mTOR Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (20): (15403). [PMID:37895083] [10.3390/ijms242015403]
3. Peng Xiong, Yang Yuping, Guo Chenqi, He Qin, Li Yan, Gong Tao, Li Jia. (2023) A sustained-release phospholipid-based phase separation gel loaded with berberine for treating rheumatoid arthritis. Frontiers in Pharmacology, 14 [PMID:37547331] [10.3389/fphar.2023.1210129]
4. Lin Yang, Chun-Feng Cheng, Zhi-Fang Li, Xiao-Jing Huang, Shao-Qing Cai, Shan-Yu Ye, Li-Jun Zhao, Yi Xiong, Dong-Feng Chen, He-Lu Liu, Zhen-Xing Ren, Hong-Cheng Fang. (2023) Berberine blocks inflammasome activation and alleviates diabetic cardiomyopathy via the miR‑18a‑3p/Gsdmd pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 51 (6): (1-13). [PMID:37114562] [10.3892/ijmm.2023.5252]
5. Jin Pian, Zhu Fucheng, Jiang Mi, Takafuji Makoto, Ihara Hirotaka, Nie Lei, Liu Houmei. (2022) Carbonized π-conjugated polymer-coated porous silica: preparation and evaluating its extraction ability for berberine. MICROCHIMICA ACTA, 189 (11): (1-15). [PMID:36190563] [10.1007/s00604-022-05496-y]
6. Shuai Wang, Yifan Zhang, Jianwei Lou, Hui Yong, Shulin Shan, Zhidan Liu, Mingxue Song, Cuiqin Zhang, Ruirui Kou, Zhaoxiong Liu, Wenhao Yu, Xiulan Zhao, Fuyong Song. (2022) The therapeutic potential of berberine chloride against SARM1-dependent axon degeneration in acrylamide-induced neuropathy. PHYTOTHERAPY RESEARCH, 37 (1): (77-88). [PMID:36054436] [10.1002/ptr.7594]
7. Hu Hong, Xu Kexing, Wang Kunping, Zhang Feng, Bai Xi. (2022) Dissecting the Effect of Berberine on the Intestinal Microbiome in the Weaned Piglets by Metagenomic Sequencing. Frontiers in Microbiology, 13 [PMID:35464928] [10.3389/fmicb.2022.862882]
8. Ying-kun Zhi, Jing Li, Lang Yi, Rui-li Zhu, Jin-fang Luo, Qing-ping Shi, Sha-sha Bai, Yan-wu Li, Qun Du, Jia-zhong Cai, Liang Liu, Pei-xun Wang, Hua Zhou, Yan Dong. (2022) Sinomenine inhibits macrophage M1 polarization by downregulating α7nAChR via a feedback pathway of α7nAChR/ERK/Egr-1. PHYTOMEDICINE, 100 (154050). [PMID:35397284] [10.1016/j.phymed.2022.154050]
9. Hao Yuan, Wan Li, Chengwu Song, Rongzeng Huang. (2022) An injectable supramolecular nanofiber-reinforced chitosan hydrogel with antibacterial and anti-inflammatory properties as potential carriers for drug delivery. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 205 (563). [PMID:35149101] [10.1016/j.ijbiomac.2022.02.015]
10. Xiao Tu, Chenxi Duan, Siwei Wu, Shengli Fu, Jianmin Ye. (2021) Identification of plumbagin as an effective chemotherapeutic agent for treatment of Gyrodactylus infections. AQUACULTURE, 535 (736372). [10.1016/j.aquaculture.2021.736372]
11. Shen Zhu-qing, Wang Juan, Tan Wen-fu, Huang Tao-min. (2020) Berberine inhibits colorectal tumor growth by suppressing SHH secretion. ACTA PHARMACOLOGICA SINICA, 42 (7): (1190-1194). [PMID:32958873] [10.1038/s41401-020-00514-2]
12. Zhen Cheng, Hongcen Dong, Jiaman Liang, Fang Zhang, Xianping Chen, Lingling Du, Kejun Tan. (2019) Highly selective fluorescent visual detection of perfluorooctane sulfonate via blue fluorescent carbon dots and berberine chloride hydrate. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 207 (262). [PMID:30253323] [10.1016/j.saa.2018.09.028]
13. Lu Jianrao, Yi Yang, Pan Ronghua, Zhang Chuanfu, Han Haiyan, Chen Jie, Liu Wenrui. (2018) Berberine protects HK-2 cells from hypoxia/reoxygenation induced apoptosis via inhibiting SPHK1 expression. Journal of Natural Medicines, 72 (2): (390-398). [PMID:29260413] [10.1007/s11418-017-1152-z]
14. Yuhan Yang, Feifei Han, Jin Ouyang, Yunling Zhao, Juan Han, Na Na. (2016) In-situ nanoelectrospray for high-throughput screening of enzymes and real-time monitoring of reactions. ANALYTICA CHIMICA ACTA, 902 (135). [PMID:26703263] [10.1016/j.aca.2015.10.032]
15. Shaoqi Qu, Shuo Yang, Qingjun Xu, Mengying Zhang, Feng Gao, Yongning Wu, Lin Li. (2024) A Milk Extracellular Vesicle-Based Nanoplatform Enhances Combination Therapy Against Multidrug-Resistant Bacterial Infections. Advanced Science, (2406496). [PMID:39721033] [10.1002/advs.202406496]
16. Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Erhui Jin, Youfang Gu, Hongyu Wang, Feng Zhang. (2025) Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome. Frontiers in Nutrition, 11 [PMID:39877539] [10.3389/fnut.2024.1494348]
17. Wang Yue, Zhang Ziting, Du Min, Ji Xu, Liu Xiaodan, Zhao Chunfang, Pang Xunsheng, Jin Erhui, Wen Aiyou, Li Shenghe, Zhang Feng. (2024) Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model. Frontiers in Immunology, 15 [PMID:39351242] [10.3389/fimmu.2024.1460127]
18. Lu Li, Bo Lin, Yu Ting, Maohui Li, Jinjin Hu, Jingjing Song, Yingjuan Yan, Jiaxin Chen, Hong Xiao, Nengguo Tao. (2024) Berberine hydrochloride delays citrus sour rot mainly by disrupting carbohydrate and energy metabolism of Geotrichum citri-aurantii spores. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 202 (105933). [PMID:38879325] [10.1016/j.pestbp.2024.105933]
19. Lijuan Xu, Rongqiang Chen, Tian Ren. (2025) Fabrication of gelatin-based photodynamic food packaging with dual-antimicrobial activity for enhanced pork preservation. FOOD HYDROCOLLOIDS, 166 (111361). [10.1016/j.foodhyd.2025.111361]
20. Li Wei, Jiao Ruofeng, Luo Shiyi, Liu Zefei, Song Jukun, Chen Zhu. (2024) Mechanism of action of Coptidis Rhizome in treating periodontitis based on network pharmacology and in vitro validation. BMC Oral Health, 24 (1): (1-12). [PMID:38704553] [10.1186/s12903-024-04311-9]
21. Hao Yuan, Zhaoxiang Zeng, Dongru Li, Rongzeng Huang, Wan Li. (2024) Multifunctional thiolated chitosan/puerarin composite hydrogels with pH/glutathione dual responsiveness for potential drug carriers. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (130841). [PMID:38553389] [10.1016/j.ijbiomac.2024.130841]
22. Ting Li, Shaojiao Song, Wei Lu, Yu Cao, Xin Zheng, Qiuyue Zhao, Hailong Wang. (2025) Nanopore characterization of DNA–COR–DNA duplex and the sensitive detection of coralyne. SENSORS AND ACTUATORS B-CHEMICAL, 430 (137407). [10.1016/j.snb.2025.137407]

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
B489860-25g	25g	现货
B489860-100g	100g	现货
B489860-500g	500g	期货

盐酸小檗碱水合物

库存信息

库存信息

库存信息

基本描述

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

此产品的引用文献

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器