| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B425666-1ml |
1ml |
期货  |
|
| 别名 | 血压(HOpic) |
|---|---|
| 英文别名 | Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V) | Bisperoxovanadium(HOpic) |
| 规格或纯度 | 10mM in Water |
| 英文名称 | bpV(HOpic) |
| 生化机理 | 抑制PTP（IC 50 = 4-25 µM）和PTEN（IC 50 = 14 nM）。胰岛素模拟物。增强PI3K / Akt信号传导，并可能防止心肌缺血再灌注损伤。在体外有活性。bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury. |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
bpV（HOpic）是与5-羟基吡啶-2-羧酸盐配位的双过氧羰基钒酸盐二钾盐。该钒化合物已被证明是蛋白磷酸酪氨酸磷酸酶（PTP）和PTEN的有效抑制剂，并已被描述为可充当胰岛素模拟物。已显示该化合物可激活肝癌细胞的胰岛素受体激酶，刺激脂肪细胞中的脂肪生成，并增强PI3K / Akt信号传导，从而防止心肌缺血再灌注（I / R）损伤。 bpV(HOpic) is a bisperoxo oxovanadate dipotassium salt coordinated to 5-hydroxypyridine-2-carboxylate. This vanadium compound has been shown to be a potent inhibitor of protein phosphotyrosine phosphatase (PTP) and PTEN, and has been described to act as an insulin mimetic. This compound has been shown to activate the insulin receptor kinase of hepatoma cells, stimulate lipogenesis in adipocytes, and to enhance PI3K/Akt signaling that could prevent ischemia-reperfusion (I/R) injury to the myocardium. |
| IC50 | PTEN: IC₅₀= 14 nM |
|---|
| Smiles | [K]OC(=O)C1=CC=C(O)C=[N]1[V]23(O[K])(OO2)OO3 |
|---|---|
| Isomeric SMILES | C1=CC(=NC=C1[O-])C(=O)O.OO.OO.O=[V].[K+].[K+] |
| PubChem CID | 54692867 |
| 分子量 | 347.24 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 |
|---|---|
| 预防措施声明 |
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 |
| WGK Germany | 3 |
| RIDADR | NONHforallmodesoftransport |
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