| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B422669-1ml |
1ml |
现货  |
|
| 英文别名 | BCP25043 | BEC HCl | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride | BEC hydrochloride | A900880 | XIA63867 | AC-29891 | AKOS030632996 | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride | S-(2-Boronoethyl)-l-cysteine |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | BEC HCl |
| 生化机理 | 盐酸溴乙酰胆碱是一种缓慢结合的竞争性精氨酸酶抑制剂，对精氨酸酶 II 和大鼠精氨酸酶 I 的Ki值分别为 0.31 μM （pH7.5）和 0.4-0.6 μM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
Information BEC HCl BEC HCl is a slow-binding, and competitive arginase inhibitor with K i of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively. Targets Arginase II ; rat Arginase I 0.31 μM(Ki); <0.6 μM(Ki) In vitro BEC causes significant enhancement of NO-dependent smooth muscle relaxation. In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK. In vivo In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure. |
| ALogP | -2.415 |
|---|---|
| Rotatable Bond | 6 |
| IIUPAC Name | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride |
|---|---|
| INCHI | 1S/C5H12BNO4S.ClH/c7-4(5(8)9)3-12-2-1-6(10)11;/h4,10-11H,1-3,7H2,(H,8,9);1H/t4-;/m0./s1 |
| InChi Key | GHPYJLCQYMAXGG-WCCKRBBISA-N |
| Smiles | B(CCSCC(C(=O)O)N)(O)O.Cl |
| Isomeric SMILES | B(CCSC[C@@H](C(=O)O)N)(O)O.Cl |
| PubChem CID | 91826515 |
| 分子量 | 229.49 |
| DMSO(mg / mL) Max Solubility | 45 |
|---|---|
| DMSO(mM) Max Solubility | 196.0869755 |
| Water(mg / mL) Max Solubility | 45 |
| Water(mM) Max Solubility | 196.0869755 |
| 分子量 | 229.490 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 5 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 229.035 Da |
| 单同位素质量Monoisotopic Mass | 229.035 Da |
| 拓扑极表面积Topological Polar Surface Area | 129.000 Ų |
| 重原子数Heavy Atom Count | 13 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 145.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
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