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基本描述
| 英文名称 | BAY-8040 |
|---|---|
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
BAY-8040 is a pyrimidopyridazine derivative which has inhibitory activity against human neutrophil elastase ( HNE ). BAY-8040 decreases cardiac remodeling and ameliorates cardiac function in a Monocrotaline -induced rat model for pulmonary arterial hypertension. BAY-8040 is promising for research of inflammatory pathologies and cardiopulmonary pathologies. |
名称和识别符
| IIUPAC Name | 4-[(4S)-7-methyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-3,4,6,8-tetrahydropyrimido[4,5-d]pyridazin-4-yl]benzonitrile |
|---|---|
| INCHI | 1S/C21H16F3N5O2/c1-28-11-16-17(19(30)27-28)18(13-7-5-12(10-25)6-8-13)26-20(31)29(16)15-4-2-3-14(9-15)21(22,23)24/h2-9,18H,11H2,1H3,(H,26,31)(H,27,30)/t18-/m0/s1 |
| InChi Key | UPNMBPLODWPJQQ-SFHVURJKSA-N |
| Smiles | CN1CC2=C(C(NC(=O)N2C3=CC=CC(=C3)C(F)(F)F)C4=CC=C(C=C4)C#N)C(=O)N1 |
| PubChem CID | 137704647 |
| MeSH Entry Terms | BAY-8040 |
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