A2ti-1

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货号 (SKU)	包装规格	是否现货
A650040-5mg	5mg	期货
A650040-10mg	10mg	期货
A650040-50mg	50mg	期货
A650040-100mg	100mg	期货

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Anti-infection (2804) HPV (11) Virus (3767) 病毒蛋白酶 (106)

基本描述

规格或纯度	≥99%
英文名称	A2ti-1
生化机理	A2ti-1 是一种选择性高亲和力附件蛋白 A2/S100A10 杂四聚体（A2t）抑制剂，IC50 为 24 μM。A2ti-1 能特异性地破坏 A2 和 S100A10 之间的蛋白-蛋白相互作用（PPI）。A2ti-1 可预防人类乳头瘤病毒 16 型
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
产品介绍	A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC 50 of 24 μM A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 ( HPV16 ) infection . In Vitro A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker. A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner. A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HeLa cells Concentration: 100 μM Incubation Time: For 72 hours Result: Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells. Form:Solid IC50& Target:IC50: 24 μM (A2t)
纯度	≥99%

名称和识别符

IIUPAC Name	2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide
INCHI	1S/C20H22N4O2S/c1-3-15-9-5-6-10-16(15)24-19(22-23-20(24)27-13-18(21)25)12-26-17-11-7-4-8-14(17)2/h4-11H,3,12-13H2,1-2H3,(H2,21,25)
InChi Key	KNQGIFUBCFRGDB-UHFFFAOYSA-N
Smiles	CCC1=CC=CC=C1N2C(=NN=C2SCC(=O)N)COC3=CC=CC=C3C
Isomeric SMILES	CCC1=CC=CC=C1N2C(=NN=C2SCC(=O)N)COC3=CC=CC=C3C
PubChem CID	1431565
分子量	382.48

化学和物理性质

溶解性	DMSO : 250 mg/mL (653.63 mM; Need ultrasonic)
分子量	382.500 g/mol
XLogP3	3.500
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	8
精确质量Exact Mass	382.146 Da
单同位素质量Monoisotopic Mass	382.146 Da
拓扑极表面积Topological Polar Surface Area	108.000 Å²
重原子数Heavy Atom Count	27
形式电荷Formal Charge	0
复杂度Complexity	481.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

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