ATP-polyamine-biotin

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货号 (SKU)	包装规格	是否现货
A649105-1mg	1mg	期货
A649105-2mg	2mg	期货
A649105-5mg	5mg	期货

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基本描述

别名	ATP-多胺-生物素
规格或纯度	≥99%
英文名称	ATP-polyamine-biotin
生化机理	ATP 多胺生物素是第一种可渗透细胞的 ATP 类似物，是一种高效的激酶共底物。ATP 多胺生物素可促进活细胞中激酶底物的生物素标记。
储存温度	避光,-80℃储存
运输条件	超低温冰袋运输
产品介绍	ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells. In Vitro ATP-polyamine-biotin (APB) is incubated with PKA kinase and full-length protein substrate, myelin basic protein (MBP). Biotinylation was observed only in presence of kinase. In addition, MBP biotinylation was lost in the absence of ATP-polyamine-biotin, in presence of the kinase inhibitor staursporine or upon incubation with acid due to cleavage of phosphoramidate bond. Biotinylated kemptide product is observed only in the presence of APB cosubstrate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
纯度	≥99%

名称和识别符

IIUPAC Name	N-[3-[4-[3-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propyl-methylamino]butyl-methylamino]propyl]-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxyphosphonamidic acid
INCHI	1S/C32H58N11O14P3S/c1-41(15-7-11-34-24(44)10-4-3-9-23-25-21(18-61-23)39-32(47)40-25)13-5-6-14-42(2)16-8-12-38-58(48,49)56-60(52,53)57-59(50,51)54-17-22-27(45)28(46)31(55-22)43-20-37-26-29(33)35-19-36-30(26)43/h19-23,25,27-28,31,45-46H,3-18H2,1-2H3,(H,34,44)(H,50,51)(H,52,53)(H2,33,35,36)(H2,38,48,49)(H2,39,40,47)/t21-,22+,23-,25-,27+,28+,31+/m0/s1
InChi Key	MODMQMYTNMWWCS-MCINONILSA-N
Smiles	CN(CCCCN(C)CCCNP(=O)(O)OP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O)CCCNC(=O)CCCCC4C5C(CS4)NC(=O)N5
PubChem CID	118704767
分子量	945.85

化学和物理性质

溶解性	H2O : 6 mg/mL (6.34 mM; Need ultrasonic and warming)

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