AP-III-a4 hydrochloride

COA

级别和纯度:

≥98%

CAS编号: 2070014-95-6
分子式: C₃₁H₄₄ClFN₈O₃
分子量: 631.18

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
A647718-2mg	2mg	期货
A647718-5mg	5mg	期货
A647718-10mg	10mg	期货
A647718-25mg	25mg	期货
A647718-50mg	50mg	期货

查看相关系列

Apoptosis (7108) Enolase (8) Glucose Metabolism (3713) Metabolic Enzyme/Protease (4889)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

别名	AP-III-a4盐酸盐
规格或纯度	≥98%
英文名称	AP-III-a4 hydrochloride
生化机理	AP-III-a4 (ENOblock) 盐酸盐是一种非底物类似物烯醇化酶抑制剂，IC 50 为 0.576 uM。AP-III-a4 盐酸盐可用于癌症和糖尿病的研究。
储存温度	2-8°C储存,干燥
运输条件	冰袋运输
作用类型	抑制剂
产品介绍	AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC 50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic In Vitro AP-III-a4 (ENOblock) (0-10 μM; 24 h) inhibits HCT116 cell viability in a dose-dependent manner. AP-III-a4 directly binds to enolase and inhibits its activity. AP-III-a4 (0-10 μM; 24 or 48 h) inhibits cancer cell migration and invasion, induces cancer cell apoptosis. AP-III-a4 (10 μM; 24 h) can induce glucose uptake and inhibit phosphoenolpyruvate carboxykinase (PEPCK) expression in hepatocytes and kidney cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 Concentration: 1.25, 2.5, 5 and 10 μM Incubation Time: 24 h Result: Induced higher levels of HCT116 colon cancer cell death in hypoxic conditions compared to normoxia. Western Blot AnalysisCell Line: HCT116 Concentration: 1.25, 2.5, 5 and 10 μM Incubation Time: 24 h for AKT, 48 h for Bcl-Xl Result: Bound to enolase in cell lysate and bound to purified enolase. Decreased the expression of AKT and Bcl-Xl, which are negative regulators of apoptosis. Cell Invasion AssayCell Line: HCT116 Concentration: 0.156, 0.312, 0.625, 1.25 and 2.5 μM Incubation Time: 24 h Result: Significantly inhibits cancer cell invasion at a treatment concentration of 0.625 μM. Cell Migration AssayCell Line: HCT116 Concentration: 0.625, 1.25 and 2.5 μM Incubation Time: 24 h Result: Inhibited cell migration dose-dependently. RT-PCRCell Line: Huh7 and HEK Concentration: 10 μM Incubation Time: 24 h Result: Induced glucose uptake and inhibited PEPCK expression. In Vivo AP-III-a4 (ENOblock) (10 μM; 96 h) inhibits cancer cell metastasis and suppresses the gluconeogenesis regulator PEPCK in zebrafish . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: The zebrafish cancer cell HCT116 xenograft model Dosage: 10 μM Administration: 96 h Result: Reduced cancer cell dissemination. Inhibited PEPCK expression and induced glucose uptake. Inhibited adipogenesis and foam cell formation. Form:Solid IC50& Target:IC 50 : 0.576 uM (enolase)
纯度	≥98%

化学和物理性质

溶解性	DMSO : ≥ 53 mg/mL (83.97 mM) H2O : <0.1 mg/mL (insoluble)

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

AP-III-a4 hydrochloride

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

名称和识别符

化学和物理性质

质检证书（CoA,COO,BSE/TSE 和分析图谱)

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器