| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A432621-1mg |
1mg |
现货  |
| |
| A432621-5mg |
5mg |
期货 |
|
| 别名 | 乙酰辅酶 A 三锂盐, 乙酰CoA |
|---|---|
| 英文别名 | Acetyl-CoA, Acetyl-S-CoA Li₃ |
| 规格或纯度 | ≥93%(HPLC) |
| 英文名称 | Acetyl coenzyme A lithium salt |
| 生化机理 | 编码乙酰辅酶A的基因的改变已与阿尔茨海默病和轻度认知障碍存在关联。该基因的缺陷可导致与阵发性呼吸暂停相关的肌无力综合征。 乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。 它可通过线粒体中丙酮酸的氧化脱羧、长链脂肪酸的氧化或某些特定氨基酸的氧化降解而形成。乙酰辅酶A是柠檬酸循环（克雷布氏循环）的起始化合物。 它也是脂质生物合成的关键前体，所有脂肪酸碳的来源。 乙酰辅酶A可正向调节丙酮酸羧化酶的活性。 它是神经递质乙酰胆碱的前体。 组蛋白乙酰化酶（HAT）使用乙酰辅酶A作为乙酰基的供体，用于组蛋白和非组蛋白蛋白的翻译后乙酰化反应。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
应用 乙酰辅酶A适用于CAT报告检测，通过将细胞提取物与0.1 μCi [ 14 C]氯霉素和0.5mM乙酰辅酶A一起孵育来对氯霉素乙酰转移酶进行测定。 酶催化乙酰基转移反应中必要的辅因子。 制备说明 酶法制备 Gene Information human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218) Application Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [ 14 C] chloramphenicol and 0.5mM acetyl-CoA. An essential cofactor in enzymatic acetyl transfer reactions. |
| 纯度 | ≥93%(HPLC) |
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | trilithium;[(2R,3S,4R,5R)-2-[[[[(3R)-4-[[3-(2-acetylsulfanylethylamino)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-3-yl] hydrogen phosphate |
| INCHI | 1S/C23H38N7O17P3S.3Li/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;;;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);;;/q;3*+1/p-3/t13-,16-,17-,18+,22-;;;/m1.../s1 |
| InChi Key | FTRFBNATWBKIQU-JHJDYNLLSA-K |
| Smiles | [Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)([O-])OP(=O)([O-])OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)[O-])O |
| Isomeric SMILES | [Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)[O-])O |
| 关联CAS | 75520-41-1 |
| 分子量 | 809.57 (free acid basis) |
| 溶解性 | H2O：可溶 100mg/mL，澄清，无色 |
|---|---|
| 敏感性 | 对湿度敏感 |
| 分子量 | 827.500 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 6 |
| 氢键受体数Hydrogen Bond Acceptor Count | 22 |
| 可旋转键计数Rotatable Bond Count | 20 |
| 精确质量Exact Mass | 827.15 Da |
| 单同位素质量Monoisotopic Mass | 827.15 Da |
| 拓扑极表面积Topological Polar Surface Area | 397.000 Ų |
| 重原子数Heavy Atom Count | 54 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1360.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 5 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 4 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| 个人防护装备 | dust mask type N95 (US)， Eyeshields， Gloves |
¥347.90
| 1. Bajpai R et al.. (2020) Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma.. Nat Commun, 11 (1228). [PMID:32144272] |
| 2. K Ohno,A Tsujino,J M Brengman,C M Harper,Z Bajzer,B Udd,R Beyring,S Robb,F J Kirkham,A G Engel. (2001-02-15) Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans.. Proceedings of the National Academy of Sciences of the United States of America, 98 ((4)): (2017-2022). [PMID:11172068] |
| 3. Simone Kraner,Iris Laufenberg,Hans M Strassburg,Joern P Sieb,Ortrud K Steinlein. (2003-05-21) Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation.. Archives of neurology, 60 ((5)): (761-763). [PMID:12756141] |
| 4. Kazima Saira,You Zhou,Clinton Jones. (2007-01-12) The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) induces degradation of interferon response factor 3 and, consequently, inhibits beta interferon promoter activity.. Journal of virology, 81 ((7)): (3077-3086). [PMID:17215277] |
| 5. Aspen Workman,Clinton Jones. (2010-04-23) Productive infection and bICP0 early promoter activity of bovine herpesvirus 1 are stimulated by E2F1.. Journal of virology, 84 ((13)): (6308-6317). [PMID:20410283] |
| 6. Whitney R Luebben,Neelam Sharma,Jennifer K Nyborg. (2010-10-27) Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14.. Proceedings of the National Academy of Sciences of the United States of America, 107 ((45)): (19254-19259). [PMID:20974913] |
| 7. Prabhjot Singh,Prija Ponnan,Nivedita Priya,Tapesh K Tyagi,Marco Gaspari,Shibu Krishnan,Giovanni Cuda,Paritosh Joshi,Jasvinder K Gambhir,Sunil K Sharma,Ashok K Prasad,Luciano Saso,Ramesh C Rastogi,Virinder S Parmar,Hanumantharao G Raj. (2011-01-18) Protein acyltransferase function of purified calreticulin: the exclusive role of P-domain in mediating protein acylation utilizing acyloxycoumarins and acetyl CoA as the acyl group donors.. Protein and peptide letters, 18 ((5)): (507-517). [PMID:21235489] |
| 8. Leticia Frizzo da Silva,Natasha Gaudreault,Clinton Jones. (2011-06-22) Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits β interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels.. Virus research, 160 ((1-2)): (143-149). [PMID:21689696] |
| 9. Juliette Adjo Aka,Go-Woon Kim,Xiang-Jiao Yang. (2011-09-01) K-acetylation and its enzymes: overview and new developments.. Handbook of experimental pharmacology, 206 (1-12). [PMID:21879443] |
| 10. Ru Li,Jing Gu,Peng Chen,Zhiping Zhang,Jiaoyu Deng,Xianen Zhang. (2011-09-08) Purification and characterization of the acetyl-CoA synthetase from Mycobacterium tuberculosis.. Acta biochimica et biophysica Sinica, 43 ((11)): (891-899). [PMID:21896569] |
| 11. Devis Sinani,Clinton Jones. (2011-09-23) Localization of sequences in a protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 that inhibits apoptosis and interferes with Notch1-mediated trans-activation of the bICP0 promoter.. Journal of virology, 85 ((23)): (12124-12133). [PMID:21937659] |
| 12. Leticia Frizzo da Silva,Devis Sinani,Clinton Jones. (2012-08-21) ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-β1) and IFN-β3.. Virus research, 169 ((1)): (162-168). [PMID:22902481] |
| 13. Swetha Vijayaraghavan,Azadeh Karami,Shahin Aeinehband,Homira Behbahani,Alf Grandien,Bo Nilsson,Kristina N Ekdahl,Rickard P F Lindblom,Fredrik Piehl,Taher Darreh-Shori. (2013-07-11) Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway.. PloS one, 8 ((6)): (e65936-e65936). [PMID:23840379] |
| 14. Xiaoguang Liu,Wei Wei,Yuting Liu,Xueli Yang,Jian Wu,Yang Zhang,Qiao Zhang,Tieliu Shi,James X Du,Yingming Zhao,Ming Lei,Jin-Qiu Zhou,Jiwen Li,Jiemin Wong. (2017-06-06) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300.. Cell discovery, 3 (17016-17016). [PMID:28580166] |
| 15. Sukru Anil Dogan,Raffaele Cerutti,Cristiane Benincá,Gloria Brea-Calvo,Howard Trevor Jacobs,Massimo Zeviani,Marten Szibor,Carlo Viscomi. (2018-08-21) Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.. Cell metabolism, 28 ((5)): (764-775). [PMID:30122554] |
| 16. Kashish Singh,Benjamin Graf,Andreas Linden,Viktor Sautner,Henning Urlaub,Kai Tittmann,Holger Stark,Ashwin Chari. (2020-03-12) Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.. Cell, 180 ((6)): (1130-1143). [PMID:32160528] |
| 17. Amit Kumar,Rajnish Kumar,John Flanagan,Bengt Långström,Lars Björndahl,Taher Darreh-Shori. (2020-09-01) Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index.. Biochemical pharmacology, 182 (114212-114212). [PMID:32866455] |
| 18. Rachel Lopez,Bahador Marzban,Xin Gao,Ellen Lauinger,Françoise Van den Bergh,Steven E Whitesall,Kimber Converso-Baran,Charles F Burant,Daniel E Michele,Daniel A Beard. (2020-10-20) Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts.. Function (Oxford, England), 1 ((2)): (zqaa018-zqaa018). [PMID:33074265] |
| 19. Zhesi Zhu,Zhen Han,Levon Halabelian,Xiangkun Yang,Jun Ding,Nawei Zhang,Liza Ngo,Jiabao Song,Hong Zeng,Maomao He,Yingming Zhao,Cheryl H Arrowsmith,Minkui Luo,Michael G Bartlett,Y George Zheng. (2020-12-15) Identification of lysine isobutyrylation as a new histone modification mark.. Nucleic acids research, 49 ((1)): (177-189). [PMID:33313896] |
| 20. Cheryl Q E Lee,Baptiste Kerouanton,Sonia Chothani,Shan Zhang,Ying Chen,Chinmay Kumar Mantri,Daniella Helena Hock,Radiance Lim,Rhea Nadkarni,Vinh Thang Huynh,Daryl Lim,Wei Leong Chew,Franklin L Zhong,David Arthur Stroud,Sebastian Schafer,Vinay Tergaonkar,Ashley L St John,Owen J L Rackham,Lena Ho. (2021-04-11) Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity.. Nature communications, 12 ((1)): (2130-2130). [PMID:33837217] |
| 21. Rebeca Acin-Perez,Cristiane Benincá,Byourak Shabane,Orian S Shirihai,Linsey Stiles. (2021-09-29) Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives.. Life (Basel, Switzerland), 11 ((9)): [PMID:34575097] |
| 22. Pengyi Yan,Zixuan Li,Junhao Xiong,Zilong Geng,Weiting Wei,Yan Zhang,Gengze Wu,Tao Zhuang,Xiaoyu Tian,Zhijie Liu,Junling Liu,Kun Sun,Fengyuan Chen,Yuzhen Zhang,Chunyu Zeng,Yu Huang,Bing Zhang. (2021-11-25) LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.. Cell reports, 37 ((8)): (110038-110038). [PMID:34818543] |
| 23. Kazima Saira,You Zhou,Clinton Jones. (2009-01-30) The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity.. Journal of virology, 83 ((8)): (3977-3981). [PMID:19176627] |
| 24. Aspen Workman,Sandra Perez,Alan Doster,Clinton Jones. (2009-06-26) Dexamethasone treatment of calves latently infected with bovine herpesvirus 1 leads to activation of the bICP0 early promoter, in part by the cellular transcription factor C/EBP-alpha.. Journal of virology, 83 ((17)): (8800-8809). [PMID:19553330] |
| 25. Aspen Workman,Devis Sinani,Daraporn Pittayakhajonwut,Clinton Jones. (2010-12-31) A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.. Journal of virology, 85 ((6)): (2536-2546). [PMID:21191019] |
| 26. Michael J Hynes,Sandra L Murray,Alex Andrianopoulos,Meryl A Davis. (2011-02-08) Role of carnitine acetyltransferases in acetyl coenzyme A metabolism in Aspergillus nidulans.. Eukaryotic cell, 10 ((4)): (547-555). [PMID:21296915] |
| 27. Jung Jae Lee,Sangmee Ahn Jo,Joon Hyuk Park,Seok Bum Lee,Inho Jo,Do Kwan Kim,Yoonseok Huh,Jong Chul Youn,Jin Hyeong Jhoo,Koung Un Park,Sung Sup Park,Dong Young Lee,Jong Inn Woo,Ki Woong Kim. (2011-05-24) Choline acetyltransferase 2384G>a polymorphism and the risk of Alzheimer disease.. Alzheimer disease and associated disorders, 26 ((1)): (81-87). [PMID:21602657] |
| 28. Leticia Frizzo da Silva,Clinton Jones. (2013-05-08) Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.. Virus research, 175 ((2)): (101-109). [PMID:23648811] |
| 29. Dennis Shin-Shian Hsu,Hsiao-Jung Wang,Shyh-Kuan Tai,Chun-Hung Chou,Chia-Hsin Hsieh,Po-Hsien Chiu,Nien-Jung Chen,Muh-Hwa Yang. (2014-10-15) Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.. Cancer cell, 26 ((4)): (534-548). [PMID:25314079] |
| 30. Alison E Ringel,Cynthia Wolberger. (2016-07-06) Structural basis for acyl-group discrimination by human Gcn5L2.. Acta crystallographica. Section D, Structural biology, 72 ((Pt 7)): (841-848). [PMID:27377381] |
| 31. Rajnish Kumar,Bengt Långström,Taher Darreh-Shori. (2016-08-11) Novel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization.. Scientific reports, 6 (31247-31247). [PMID:27507101] |
| 32. Amit Kumar,Erica Lana,Rajnish Kumar,Christina Unger Lithner,Taher Darreh-Shori. (2018-10-03) Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase.. Frontiers in molecular neuroscience, 11 (327-327). [PMID:30271321] |
| 33. Sumonto Mitra,Giorgio Turconi,Taher Darreh-Shori,Kärt Mätlik,Matilde Aquilino,Maria Eriksdotter,Jaan-Olle Andressoo. (2021-09-04) Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers.. Frontiers in aging neuroscience, 13 (714186-714186). [PMID:34475820] |
首页
400-620-6333
I2518770