| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A408248-1ml |
1ml |
现货  |
|
| 英文别名 | NAC | N-acetyl-L-cysteine |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Acetylcysteine (N-acetylcysteine)（ NAC） |
| 生化机理 | 乙酰半胱氨酸（N-acetyl-l-cysteine，NAC）是一种 ROS（活性氧）抑制剂，可拮抗蛋白酶体抑制剂的活性。它还是一种肿瘤坏死因子生成抑制剂。乙酰半胱氨酸（N-乙酰-L-半胱氨酸）通过抑制 IκB 激酶抑制 TNF 诱导的 NF-κB 激活。乙酰半胱氨酸（N-乙酰-L-半胱氨酸）通过线粒体依赖途径诱导细胞凋亡。乙酰半胱氨酸（N-乙酰-L-半胱氨酸）可抑制铁变态反应和病毒复制。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用机制 | 溶菌酶 |
| 产品介绍 |
Information Acetylcysteine (N-acetyl-l-cysteine, NAC) is aROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also atumor necrosis factor productioninhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-inducedN N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. In vivo N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 0.4 |
|---|
| EC号 | 210-498-3 |
|---|---|
| Isomeric SMILES | CC(=O)N[C@@H](CS)C(=O)O |
| 分子量 | 163.19 |
| Beilstein号 | 1724426 |
| Reaxy-Rn | 1724426 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1724426&ln= |
| 溶解性 | Solubility (25°C) In vitro DMSO: 64 mg/mL (198.51 mM); Ethanol: 64 mg/mL (198.51 mM); Water: Insoluble; |
|---|---|
| 比旋光度 | 24 ° (JPC Method) |
| 熔点 | 109-111°C |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H319: 引起严重眼睛刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 2 |
| RTECS | HA1660000 |
| Merck Index | 88 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
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