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丫啶橙 半氯化锌盐

细胞可渗透的变色荧光阳离子DNA和RNA染料；RNA聚合酶抑制剂。
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货号 (SKU) 包装规格 是否现货 价格 数量
A100495-250mg
 250mg 现货 Stock Image
A100495-1g
 1g 现货 Stock Image
A100495-5g
 5g 现货 Stock Image
A100495-25g
 25g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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基本描述

别名 碱性橙 14 | 3,6-双(二甲基氨基)吖啶氯化物半(氯化锌盐) | 3,6-双(二甲基氨基)吖啶盐酸盐 氯化锌复盐 | 吖啶橙GNY | 吖啶橙3RX
英文别名 C.I. 46005 | Euchrysin GNY | Euchrysine 3RX | AKOS027250830 | N,N,N inverted exclamation marka,N inverted exclamation marka-Tetramethylacridine-3,6-diamine monohydrochloride compd. with zinc dichloride | BasicOrange14 | DTXSID20906035 | N,N,N',N'-Tetramet
规格或纯度 用于电泳
英文名称 Acridine Orange hemi(zinc chloride) salt
生化机理 可渗透细胞的变色荧光阳离子染料，可染色DNA和RNA。也是RNA聚合酶的抑制剂。
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

溶于水、乙醇。溶液为橙黄色带绿色荧光。pH值为8.4～10.4则无荧光。能镶嵌于两个相邻的碱基对之间，使部分双螺旋DNA松开，该两个碱基对的距离拉大一倍。这样的DNA复制过程中，会使DNA链增加或缺失一个碱基，造成移码突变。Colour Index Number 46005 用作荧光指示剂，肿瘤细胞及细菌、核酸染色剂及移码突变的诱变剂。 吖啶橙是一种荧光色素，吖啶橙激发滤光片波长488nm。阻断滤光片波长515nm。吖啶橙与细胞中DNA和RNA结合量存在差别，可发出不同颜色的荧光（即着色特异性），这是由于DNA是个高度聚合物，吸收荧光物质的位置较少，发绿色荧光，而RNA聚合度低，能和荧光物质结合的位置多，故发红色荧光。


用途

适合

检测凝胶电泳分离的核酸

荧光和落射荧光显微镜

流式细胞术分析线粒体和溶酶体

凋亡研究中的DNA染色

吖啶橙是一种细胞可渗透的异染色荧光阳离子染料，可嵌入 DNA 和 RNA，用于荧光和表观显微镜检测。吖啶橙染料已被用于通过流式细胞术分析线粒体和溶酶体含量，表征多药耐药性以及检测大鼠胸腺细胞凋亡过程中线粒体质量的变化。

Acridine Orange hemi (zinc chloride) salt is a cell-permeable metachromatic fluorescent dye that stains DNA and RNA. This dye is also an inhibitor of RNA polymerase.
Fluorescent dye that stains DNA and RNA


Application

Suitable for

detection of nucleic acids separated by gel electrophoresis

fluorescence and epifluorescence microscopy

analysis of mitochondria and lysosomes by flow cytometry

DNA staining in apoptosis studies

Acridine Orange, a cell-permeable metachromatic fluorescent cationic dye that intercalates DNA and RNA, is used in fluorescence and epiflouresence microscopy. Acridine Orange dye has been used to analyze mitochondria and lysosomal content by flow cytometry, characterize multidrug resistance, and measure changes in mitochondrial mass during apoptosis in rat thymocytes.

名称和识别符

EC号 233-353-6
IIUPAC Name zinc;3-N,3-N,6-N,6-N-tetramethylacridine-3,6-diamine;dichloride;hydrochloride
INCHI 1S/C17H19N3.3ClH.Zn/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14;;;;/h5-11H,1-4H3;3*1H;/q;;;;+2/p-2
InChi Key VADJQOXWNSPOQA-UHFFFAOYSA-L
Smiles CN(C)C1=CC2=C(C=C1)C=C3C=CC(=CC3=N2)N(C)C.Cl.[Cl-].[Cl-].[Zn+2]
Isomeric SMILES CN(C)C1=CC2=C(C=C1)C=C3C=CC(=CC3=N2)N(C)C.Cl.[Cl-].[Cl-].[Zn+2]
PubChem CID 159263
分子量 369.96
Beilstein号 3734978
Reaxy-Rn 10510633

化学和物理性质

溶解性 Soluble in water (1 mg/ml).
密度 2.54
敏感性 对湿度敏感
分子量 438.100 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 435.001 Da
单同位素质量Monoisotopic Mass 435.001 Da
拓扑极表面积Topological Polar Surface Area 19.400 Ų
重原子数Heavy Atom Count 24
形式电荷Formal Charge 0
复杂度Complexity 298.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 5

安全和危险性（GHS）

象形图 GHS08
信号词 警告
危险声明

H341: 怀疑引起遗传缺陷
预防措施声明

P281: 根据需要使用个人防护设备。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P203: 使用前，获取、阅读并遵守所有安全说明。

P318: 如果暴露或担心，请就医。
WGK Germany 3
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
I2108064 分析证书 A100495
F2124018 分析证书 A100495
F1529001 分析证书 A100495
F2509044 分析证书 A100495
G2216055 分析证书 A100495
G2216079 分析证书 A100495
I2205456 分析证书 A100495
H2507150 分析证书 A100495
F2207282 分析证书 A100495

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引用文献

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