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Zalifrelimab (anti-CTLA-4) - Primary antibody, specific to CTLA4, Human IgG1, INHIBITOR of Cytotoxic T-lymphocyte protein 4 inhibitor, INHIBITOR of Cytotoxic T-lymphocyte protein 4 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182811
Grouped product items
SKU Size
Availability
Price Qty
Ab182811-100μg
100μg
10
$109.90
Ab182811-1mg
1mg
4
$519.90
Ab182811-5mg
5mg
1
$1,399.90
Ab182811-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Zalifrelimab (anti-CTLA-4) - Primary antibody, specific to CTLA4, Human IgG1, INHIBITOR of Cytotoxic T-lymphocyte protein 4 inhibitor
Synonyms ALPS5 antibody | CD 152 antibody | CD antibody | CD152 antibody | CD152 antigen antibody | CD152 isoform antibody | Celiac disease 3 antibody | CELIAC3 antibody | CTLA 4 antibody | CTLA-4 antibody | CTLA4 antibody | CTLA4_HUMAN antibody | Cytotoxic T cell
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CTLA4
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Cytotoxic T-lymphocyte protein 4 inhibitor
Product Description

Zalifrelimab (anti-CTLA-4) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab (anti-CTLA-4) antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.6 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 203.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2148321-69-9

Associated Targets(Human)

CTLA4 Tclin Cytotoxic T-lymphocyte protein 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Zalifrelimab (anti-CTLA-4) (Ab182811) - Flow Cytometry
huCTLA-4-CHO-K cells were stained with Zalifrelimab (anti-CTLA-4) (Ab182811) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC ₅₀ is 0.51 μg/mL.

Zalifrelimab (anti-CTLA-4) (Ab182811) - ELISA
Immobilized Recombinant Human CTLA-4 Protein (rp176276) at 1.0 μg/mL can bind Zalifrelimab (anti-CTLA-4) (Ab182811) with the EC ₅₀  of 26.83 ng/mL.

Zalifrelimab (anti-CTLA-4) (Ab182811) - SEC
The purity of Zalifrelimab (anti-CTLA-4) (Ab182811) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708325 Certificate of Analysis Jul 16, 2024 Ab182811
ZJ24F0708324 Certificate of Analysis Jul 16, 2024 Ab182811
ZJ24F0708323 Certificate of Analysis Jul 16, 2024 Ab182811

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