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XmAb 5592 (anti-BST2) - Primary antibody, specific to BST2, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab190137
Grouped product items
SKU Size
Availability
Price Qty
Ab190137-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
Ab190137-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$389.90
Ab190137-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,049.90
Ab190137-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,679.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name XmAb 5592 (anti-BST2) - Primary antibody, specific to BST2, Human IgG1
Synonyms Bone marrow stromal antigen 2 antibody | Bone marrow stromal cell antigen 2 antibody | Bone marrow stromal cell antigen antibody | BST 2 antibody | BST-2 antibody | BST2 antibody | BST2_HUMAN antibody | CD 317 antibody | CD317 antibody | CD317 antigen ant
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity BST2
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

XmAb 5592 (anti-BST2) is a humanized, Fc-engineered anti-HM1.24 antibody with enhanced binding to FcγRIIIa and FcγRIIa receptors, augments HM1.24-specific multiple myeloma (MM) cells lysis in vitro via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP).
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1221901-33-2

Associated Targets(Human)

BST2 Tbio Bone marrow stromal antigen 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

XmAb 5592 (anti-BST2) (Ab190137) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling BST2 (red) with XmAb 5592 (anti-BST2) (Ab190137). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

XmAb 5592 (anti-BST2) (Ab190137) - SEC
The purity of XmAb 5592 (anti-BST2) (Ab190137) is more than 95% verified by HPLC.

XmAb 5592 (anti-BST2) (Ab190137) - ELISA
Immobilized Recombinant Human BST2/Tetherin protein (rp183660) at 1.0 μg/mL can bind XmAb 5592 (anti-BST2) (Ab190137) with the EC ₅₀  of 18.08 ng/mL.

XmAb 5592 (anti-BST2) (Ab190137) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling BST2 (red) with XmAb 5592 (anti-BST2) (Ab190137). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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