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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab190137-100μg
|
100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$79.90
|
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Ab190137-1mg
|
1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$389.90
|
|
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Ab190137-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,049.90
|
|
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Ab190137-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,679.90
|
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | XmAb 5592 (anti-BST2) - Primary antibody, specific to BST2, Human IgG1 |
|---|---|
| Synonyms | Bone marrow stromal antigen 2 antibody | Bone marrow stromal cell antigen 2 antibody | Bone marrow stromal cell antigen antibody | BST 2 antibody | BST-2 antibody | BST2 antibody | BST2_HUMAN antibody | CD 317 antibody | CD317 antibody | CD317 antigen ant |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | BST2 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
XmAb 5592 (anti-BST2) is a humanized, Fc-engineered anti-HM1.24 antibody with enhanced binding to FcγRIIIa and FcγRIIa receptors, augments HM1.24-specific multiple myeloma (MM) cells lysis in vitro via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1221901-33-2 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
XmAb 5592 (anti-BST2) (Ab190137) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling BST2 (red) with XmAb 5592 (anti-BST2) (Ab190137). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
XmAb 5592 (anti-BST2) (Ab190137) - SEC
The purity of XmAb 5592 (anti-BST2) (Ab190137) is more than 95% verified by HPLC.
XmAb 5592 (anti-BST2) (Ab190137) - ELISA
Immobilized Recombinant Human BST2/Tetherin protein (rp183660) at 1.0 μg/mL can bind XmAb 5592 (anti-BST2) (Ab190137) with the EC
₅₀
of 18.08 ng/mL.
XmAb 5592 (anti-BST2) (Ab190137) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling BST2 (red) with XmAb 5592 (anti-BST2) (Ab190137). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.