Skip to the beginning of the images gallery

Valganciclovir HCl - ≥99%, high purity , Human herpesvirus 1 DNA polymerase inhibitor, CAS No.175865-59-5, Human herpesvirus 1 DNA polymerase inhibitor

1 Citations

COA

Grade & Purity:

≥99%

Cas Number: 175865-59-5
Molecular Weight: 390.82
MDL number: MFCD08460118
PubChem CID: 135413534
PubChem SID: 488202864

In stock

Item Number

V129457

Grouped product items
SKU	Size	Availability	Price
V129457-10mg	10mg	3	$25.90
V129457-50mg	50mg	3	$107.90
V129457-250mg	250mg	3	$486.90
V129457-1g	1g	3	$1,749.90
V129457-5g	5g	2	$7,873.90

Antiviral agent. prodrug of Ganciclovcir.

View related series

Anti-infection (2803) CMV (33) Pharmaceutical ingredients (367) Virus (1811)

Basic Description

Synonyms	NCGC00168779-01 \| CS-1755 \| DTXSID9046784 \| ZORWARFPXPVJLW-MTFPJWTKSA-N \| 2-((2-amino-6-oxo-3,6-dihydro-9h-purin-9-yl)methoxy)-3-hydroxypropyl l-valinate hcl \| RS-79070 \| VALGANCICLOVIR HYDROCHLORIDE (USP-RS) \| J-011142 \| Valganciclovir hydrochloride [USA
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Antiviral agent. Orally active prodrug of Ganciclovcir ( Asc 1467 ). Undergoes rapid conversion to Ganciclovir by esterases in vivo. Competitively inhibits the incorporation of dGTP by viral DNA polymerase.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Human herpesvirus 1 DNA polymerase inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acid esters

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Alpha amino acid esters
Alternative Parents	Valine and derivatives 6-oxopurines Hypoxanthines Aminopyrimidines and derivatives Fatty acid esters Glycerolipids Pyrimidones N-substituted imidazoles Heteroaromatic compounds Vinylogous amides Carboxylic acid esters Monocarboxylic acids and derivatives Azacyclic compounds Monoalkylamines Carbonyl compounds Hydrochlorides Hydrocarbon derivatives Organic oxides Organopnictogen compounds Primary alcohols
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Alpha-amino acid ester - Valine or derivatives - 6-oxopurine - Hypoxanthine - Purine - Imidazopyrimidine - Aminopyrimidine - Pyrimidone - Glycerolipid - Fatty acid ester - Pyrimidine - Fatty acyl - N-substituted imidazole - Imidazole - Vinylogous amide - Azole - Heteroaromatic compound - Carboxylic acid ester - Azacycle - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Organic nitrogen compound - Organonitrogen compound - Primary aliphatic amine - Organooxygen compound - Primary alcohol - Primary amine - Hydrochloride - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488202864
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202864
IUPAC Name	[2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate;hydrochloride
INCHI	InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
InChIKey	ZORWARFPXPVJLW-MTFPJWTKSA-N
Smiles	CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N.Cl
Isomeric SMILES	CC(C)[C@@H](C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N.Cl
PubChem CID	135413534
Molecular Weight	390.82

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
G23201200	Certificate of Analysis	May 09, 2025	V129457
G23201190	Certificate of Analysis	May 09, 2025	V129457
G23201207	Certificate of Analysis	May 09, 2025	V129457
G23201186	Certificate of Analysis	May 09, 2025	V129457
G23201199	Certificate of Analysis	May 09, 2025	V129457
G23201201	Certificate of Analysis	May 09, 2025	V129457
G23201206	Certificate of Analysis	May 09, 2025	V129457
G23201196	Certificate of Analysis	May 09, 2025	V129457
E1526060	Certificate of Analysis	Oct 23, 2024	V129457
C2421800	Certificate of Analysis	Mar 30, 2024	V129457
C2421789	Certificate of Analysis	Mar 29, 2024	V129457

Show more⌵

Chemical and Physical Properties

Solubility	Soluble in DMSO, Methanol and Water
Melt Point(°C)	162-164°C
Molecular Weight	390.820 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	390.142 Da
Monoisotopic Mass	390.142 Da
Topological Polar Surface Area	167.000 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	528.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Weiwei Tao, Jie Ruan, Ruyan Wu, Min Zhao, Tong Zhao, Mingming Qi, Sonata S.Y. Yau, Guangda Yao, Hongru Zhang, Yue Hu, Gang Chen. (2023) A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt/β-catenin signaling. Journal of Advanced Research, 43 (219).

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration