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CMV
Valganciclovir HCl - 10mM in DMSO, high purity , CAS No.175865-59-5, Human herpesvirus 1 DNA polymerase inhibitor

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Valganciclovir HCl - 10mM in DMSO, high purity , CAS No.175865-59-5, Human herpesvirus 1 DNA polymerase inhibitor

1 Citations

COA

Grade & Purity:

10mM in DMSO

Cas Number: 175865-59-5
Molecular Weight: 390.82
PubChem CID: 135413534

In stock

Item Number

V422149

Grouped product items
SKU	Size	Availability	Price	Qty
V422149-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$241.90

Antiviral agent. prodrug of Ganciclovcir.

View related series

Compound libraries (12325) Virus (1811)

Basic Description

Synonyms	Valganciclovir hydrochloride \| 175865-59-5 \| Valganciclovir HCl \| Valcyte \| Valcyt \| Valganciclovir (hydrochloride) \| UNII-4P3T9QF9NZ \| RS 079070-194 \| DTXSID9046784 \| RO 107-9070/194 \| RS-79070-194 \| NSC-760349 \| 4P3T9QF9NZ \| DTXCID7026784 \| Ro107-9070/194 \| RS-079070-194 \| Cymeval \| NSC
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Antiviral agent. Orally active prodrug of Ganciclovcir ( Asc 1467 ). Undergoes rapid conversion to Ganciclovir by esterases in vivo. Competitively inhibits the incorporation of dGTP by viral DNA polymerase.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Human herpesvirus 1 DNA polymerase inhibitor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acid esters

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Alpha amino acid esters
Alternative Parents	Valine and derivatives 6-oxopurines Hypoxanthines Aminopyrimidines and derivatives Fatty acid esters Glycerolipids Pyrimidones N-substituted imidazoles Heteroaromatic compounds Vinylogous amides Carboxylic acid esters Monocarboxylic acids and derivatives Azacyclic compounds Monoalkylamines Carbonyl compounds Hydrochlorides Hydrocarbon derivatives Organic oxides Organopnictogen compounds Primary alcohols
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Alpha-amino acid ester - Valine or derivatives - 6-oxopurine - Hypoxanthine - Purine - Imidazopyrimidine - Aminopyrimidine - Pyrimidone - Glycerolipid - Fatty acid ester - Pyrimidine - Fatty acyl - N-substituted imidazole - Imidazole - Vinylogous amide - Azole - Heteroaromatic compound - Carboxylic acid ester - Azacycle - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Organic nitrogen compound - Organonitrogen compound - Primary aliphatic amine - Organooxygen compound - Primary alcohol - Primary amine - Hydrochloride - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate;hydrochloride
INCHI	InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
InChIKey	ZORWARFPXPVJLW-MTFPJWTKSA-N
Smiles	CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N.Cl
Isomeric SMILES	CC(C)[C@@H](C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N.Cl
PubChem CID	135413534
Molecular Weight	390.82

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Melt Point(°C)	162-164°C
Molecular Weight	390.820 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	390.142 Da
Monoisotopic Mass	390.142 Da
Topological Polar Surface Area	167.000 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	528.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Weiwei Tao, Jie Ruan, Ruyan Wu, Min Zhao, Tong Zhao, Mingming Qi, Sonata S.Y. Yau, Guangda Yao, Hongru Zhang, Yue Hu, Gang Chen. (2023) A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt/β-catenin signaling. Journal of Advanced Research, 43 (219).

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