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Ulocuplumab (anti-CXCR4) - Primary antibody, specific to CXCR4, >95%, high purity, Human IgG4SP, INHIBITOR of C-X-C chemokine receptor type 4 inhibitor, INHIBITOR of C-X-C chemokine receptor type 4 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab175993
Grouped product items
SKU Size
Availability
Price Qty
Ab175993-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab175993-1mg
1mg
5
$289.90
Ab175993-5mg
5mg
1
$749.90
Ab175993-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Ulocuplumab (anti-CXCR4) - Primary antibody, specific to CXCR4, >95%, high purity, Human IgG4SP, INHIBITOR of C-X-C chemokine receptor type 4 inhibitor
Synonyms CXCR-4 | CXC-R4 | FB22 | Fusin | HM89 | LAP-3 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | Lipopolysaccharide-associated protein 3 | LPS-associated protein 3 | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CXCR4
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of C-X-C chemokine receptor type 4 inhibitor
Product Description

Ulocuplumab (anti-CXCR4) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab (anti-CXCR4) induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab (anti-CXCR4) exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.7 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 187.4 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1375830-34-4

Associated Targets(Human)

CXCR4 Tclin C-X-C chemokine receptor type 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Ulocuplumab (anti-CXCR4) (Ab175993) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CXCR4 (red) with Ulocuplumab (anti-CXCR4) (Ab175993). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1101850 Certificate of Analysis Nov 29, 2023 Ab175993
ZJ23F1101849 Certificate of Analysis Nov 29, 2023 Ab175993

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