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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175993-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$59.90
|
|
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Ab175993-1mg
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1mg |
5
|
$289.90
|
|
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Ab175993-5mg
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5mg |
1
|
$749.90
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|
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Ab175993-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,189.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Ulocuplumab (anti-CXCR4) - Primary antibody, specific to CXCR4, >95%, high purity, Human IgG4SP, INHIBITOR of C-X-C chemokine receptor type 4 inhibitor |
|---|---|
| Synonyms | CXCR-4 | CXC-R4 | FB22 | Fusin | HM89 | LAP-3 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | Lipopolysaccharide-associated protein 3 | LPS-associated protein 3 | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | CXCR4 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of C-X-C chemokine receptor type 4 inhibitor |
| Product Description |
Ulocuplumab (anti-CXCR4) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab (anti-CXCR4) induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab (anti-CXCR4) exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.7 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 187.4 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1375830-34-4 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Ulocuplumab (anti-CXCR4) (Ab175993) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CXCR4 (red) with Ulocuplumab (anti-CXCR4) (Ab175993). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 29, 2023 | Ab175993 | |
| Certificate of Analysis | Nov 29, 2023 | Ab175993 |
Starting at $72.90
Starting at $72.90
Starting at $59.90
Starting at $49.90
Starting at $72.90