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U3-1784 (anti-FGFR4) - Primary antibody, specific to FGFR4, >95%, high purity, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab177857
Grouped product items
SKU Size
Availability
Price Qty
Ab177857-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab177857-1mg
1mg
5
$519.90
Ab177857-5mg
5mg
1
$1,399.90
Ab177857-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name U3-1784 (anti-FGFR4) - Primary antibody, specific to FGFR4, >95%, high purity, Human IgG1
Synonyms EC 2.7.10.1 | FGFR-4
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity FGFR4
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

U3-1784 (anti-FGFR4) is a human monoclonal antibody targeting FGFR4 (human fibroblast growth factor receptor 4), with potential antineoplastic activity. It blocks activation of FGFR4, which inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells.

Product Properties

Isotype Human IgG1
Light Chain Type lambda
SDS-PAGE 27.7 kDa (Light Chain) & 50.5 kDa (Heavy Chain), under reducing conditions; 186.9 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

FGFR4 Tclin Fibroblast growth factor receptor 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
FGFR4 Tclin Fibroblast growth factor receptor 4 (3668 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FGFR4 Tclin FGFR4-KLB (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

U3-1784 (anti-FGFR4) (Ab177857) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling FGFR4 (red) with U3-1784 (anti-FGFR4) (Ab177857). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

U3-1784 (anti-FGFR4) (Ab177857) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling FGFR4 (red) with U3-1784 (anti-FGFR4) (Ab177857). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

U3-1784 (anti-FGFR4) (Ab177857) - SEC
The purity of U3-1784 (anti-FGFR4) (Ab177857) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1202214 Certificate of Analysis Dec 28, 2023 Ab177857
ZJ23F1202213 Certificate of Analysis Dec 28, 2023 Ab177857

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