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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab177857-100μg
|
100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$109.90
|
|
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Ab177857-1mg
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1mg |
5
|
$519.90
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|
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Ab177857-5mg
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5mg |
1
|
$1,399.90
|
|
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Ab177857-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,239.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | U3-1784 (anti-FGFR4) - Primary antibody, specific to FGFR4, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | EC 2.7.10.1 | FGFR-4 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | FGFR4 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
U3-1784 (anti-FGFR4) is a human monoclonal antibody targeting FGFR4 (human fibroblast growth factor receptor 4), with potential antineoplastic activity. It blocks activation of FGFR4, which inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | lambda |
| SDS-PAGE | 27.7 kDa (Light Chain) & 50.5 kDa (Heavy Chain), under reducing conditions; 186.9 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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U3-1784 (anti-FGFR4) (Ab177857) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling FGFR4 (red) with U3-1784 (anti-FGFR4) (Ab177857). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
U3-1784 (anti-FGFR4) (Ab177857) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling FGFR4 (red) with U3-1784 (anti-FGFR4) (Ab177857). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
U3-1784 (anti-FGFR4) (Ab177857) - SEC
The purity of U3-1784 (anti-FGFR4) (Ab177857) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Dec 28, 2023 | Ab177857 | |
| Certificate of Analysis | Dec 28, 2023 | Ab177857 |