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Tifcemalimab (anti-BTLA) - Primary antibody, specific to BTLA, Human IgG4SP

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182990
Grouped product items
SKU Size
Availability
Price Qty
Ab182990-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab182990-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$289.90
Ab182990-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$749.90
Ab182990-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Tifcemalimab (anti-BTLA) - Primary antibody, specific to BTLA, Human IgG4SP
Synonyms B and T lymphocyte attenuator antibody | B and T lymphocyte associated protein antibody | B and T lymphocyte associated antibody | B- and T-lymphocyte attenuator antibody | B- and T-lymphocyte-associated protein antibody | JS004 | MGC129743 | BTLA antibod
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. Post-translational: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
Host species Human
Specificity BTLA
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Tifcemalimab (anti-BTLA) is a humanized anti-BTLA (B and T lymphocyte attenuation factor) monoclonal antibody. Tifcemalimab (anti-BTLA) blocks the interaction of HVEM-BTLA by binding to BTLA, and thus blocks the inhibitory signaling pathway mediated by BTLA. Tifcemalimab (anti-BTLA) can be used in research of cancer.

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 146 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

BTLA Tbio B- and T-lymphocyte attenuator (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Tifcemalimab (anti-BTLA) (Ab182990) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling BTLA with Tifcemalimab (anti-BTLA) (Ab182990) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Tifcemalimab (anti-BTLA) (Ab182990) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling BTLA (red) with Tifcemalimab (anti-BTLA) (Ab182990) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Tifcemalimab (anti-BTLA) (Ab182990) - ELISA
Immobilized Recombinant Human BTLA protein (rp143904) at 1.0 μg/mL can bind Tifcemalimab (anti-BTLA) (Ab182990) with the EC₅₀ of 130.30 ng/mL.

Tifcemalimab (anti-BTLA) (Ab182990) - SEC
The purity of Tifcemalimab (anti-BTLA) (Ab182990) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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