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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab177880-100μg
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100μg |
10
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$109.90
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Ab177880-1mg
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1mg |
4
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$539.90
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Ab177880-5mg
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5mg |
1
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$1,349.90
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Ab177880-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$2,159.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Talacotuzumab (anti-IL-3Ra) - Primary antibody, specific to IL3RA, >95%, high purity, Human IgG1, BINDING AGENT of Interleukin-3 receptor subunit alpha binding agent |
|---|---|
| Synonyms | IL-3 receptor subunit alpha | IL-3R subunit alpha | IL-3RA | IL-3R-alpha |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL3RA |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | BINDING AGENT of Interleukin-3 receptor subunit alpha binding agent |
| Product Description |
Talacotuzumab (anti-IL-3Ra) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab (anti-IL-3Ra) has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab (anti-IL-3Ra) inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab (anti-IL-3Ra) has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab (anti-IL-3Ra) is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 191.5 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1826831-79-1 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra (red) with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Talacotuzumab (anti-IL-3Ra) (Ab177880) - SEC
The purity of Talacotuzumab (anti-IL-3Ra) (Ab177880) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 03, 2024 | Ab177880 | |
| Certificate of Analysis | Apr 03, 2024 | Ab177880 | |
| Certificate of Analysis | Apr 03, 2024 | Ab177880 |
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