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Talacotuzumab (anti-IL-3Ra) - Primary antibody, specific to IL3RA, >95%, high purity, Human IgG1, BINDING AGENT of Interleukin-3 receptor subunit alpha binding agent, BINDING AGENT of Interleukin-3 receptor subunit alpha binding agent

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab177880
Grouped product items
SKU Size
Availability
Price Qty
Ab177880-100μg
100μg
10
$109.90
Ab177880-1mg
1mg
4
$539.90
Ab177880-5mg
5mg
1
$1,349.90
Ab177880-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,159.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Talacotuzumab (anti-IL-3Ra) - Primary antibody, specific to IL3RA, >95%, high purity, Human IgG1, BINDING AGENT of Interleukin-3 receptor subunit alpha binding agent
Synonyms IL-3 receptor subunit alpha | IL-3R subunit alpha | IL-3RA | IL-3R-alpha
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL3RA
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type BINDING AGENT
Mechanism of action BINDING AGENT of Interleukin-3 receptor subunit alpha binding agent
Product Description

Talacotuzumab (anti-IL-3Ra) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab (anti-IL-3Ra) has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab (anti-IL-3Ra) inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab (anti-IL-3Ra) has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab (anti-IL-3Ra) is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 27.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 191.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1826831-79-1

Associated Targets(Human)

IL3RA Tclin Interleukin-3 receptor subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Talacotuzumab (anti-IL-3Ra) (Ab177880) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL-3Ra (red) with Talacotuzumab (anti-IL-3Ra) (Ab177880) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Talacotuzumab (anti-IL-3Ra) (Ab177880) - SEC
The purity of Talacotuzumab (anti-IL-3Ra) (Ab177880) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404127 Certificate of Analysis Apr 03, 2024 Ab177880
ZJ24F0404126 Certificate of Analysis Apr 03, 2024 Ab177880
ZJ24F0404125 Certificate of Analysis Apr 03, 2024 Ab177880

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