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Tadocizumab (anti-Integrin α2β3) - Primary antibody, specific to ITGA2; ITGB3, Human IgG1, ANTAGONIST of Integrin alpha-IIb/beta-3 antagonist, ANTAGONIST of Integrin alpha-IIb/beta-3 antagonist

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab183432
Grouped product items
SKU Size
Availability
Price Qty
Ab183432-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab183432-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab183432-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,299.90
Ab183432-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,079.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level ≤ 0.01EU/μg ; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Tadocizumab (anti-Integrin α2β3) - Primary antibody, specific to ITGA2; ITGB3, Human IgG1, ANTAGONIST of Integrin alpha-IIb/beta-3 antagonist
Synonyms C4G1 | YM-337 | BR antibody | CD 49b antibody | CD49 antigen like family member B antibody | CD49 antigen-like family member B antibody | CD49b antibody | CD49b antigen antibody | Collagen receptor antibody | DX5 antibody | Glycoprotein Ia deficiency incl
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ITGA2; ITGB3
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action ANTAGONIST of Integrin alpha-IIb/beta-3 antagonist
Product Description

Tadocizumab (anti-Integrin α2β3) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab (anti-Integrin α2β3) has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research.

Purity≥95% (SDS-PAGE&SEC)

Endotoxin Level ≤ 0.01EU/μg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145.3 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 339086-80-5

Associated Targets(Human)

ITGB3 Tclin Integrin beta-3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA2 Tbio Integrin alpha-2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA2 Tbio Integrin alpha-2 (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-IIb/beta-3 (3481 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) (39 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-V/beta-3 and alpha-IIb/beta 3 (49 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-2/beta-3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-3/beta-3 (47 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Tadocizumab (anti-Integrin α2β3) (Ab183432) - Flow Cytometry
Flow Cytometry analysis of U-2 OS cells labelling Integrin α2β3 (red) with Tadocizumab (anti-Integrin α2β3) (Ab183432). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Tadocizumab (anti-Integrin α2β3) (Ab183432) - ELISA
Immobilized Recombinant Human Integrin alpha 2b beta 3(ITGAIIb&ITGB3) Heterodimer protein, His Tag Free at 2.0 μg/mL can bind Tadocizumab (anti-Integrin α2β3) (Ab183432) with the EC ₅₀  of 4.164 ng/mL.

Tadocizumab (anti-Integrin α2β3) (Ab183432) - SEC
The purity of Tadocizumab (anti-Integrin α2β3) (Ab183432) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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