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Description générale
| Synonymes | Oxamic acid, sodium salt | EINECS 209-290-5 | O 2751 | HY-W013032A | FT-0632400 | MFCD00044553 | NCGC00261598-01 | Oxamic acid sodium salt | Acetic acid, aminooxo-, monosodium salt | AKOS024462579 | EU-0100913 | DTXSID1060342 | Oxamic acid (sodium) | A853 |
|---|---|
| Spécifications et pureté | ≥98% |
| Mécanismes biochimiques et physiologiques | Weak lactate dehydrogenase inhibitor (IC 50 values are 600 and 4400 μM in H460 and A549 cells respectively). Inhibits glycolysis and gluconeogenesis. Pyruvate analog. Decreases extracellular acidification rate. |
| Température de stockage | Room temperature |
| Expédié en | Normal |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Sodium oxamate is an inhibitor of gluconeogenesis and glycolysis. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.
Application |
Taxonomic Classification
Taxonomy Tree
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Kingdom
Organic compounds
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Superclass
Organic acids and derivatives
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Classe
Carboxylic acids and derivatives
- Subclass Amino acids, peptides, and analogues
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Classe
Carboxylic acids and derivatives
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Superclass
Organic acids and derivatives
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Classe | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives |
| Direct Parent | Alpha amino acids and derivatives |
| Alternative Parents | Primary carboxylic acid amides Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Alpha-amino acid or derivatives - Carboxamide group - Carboxylic acid salt - Primary carboxylic acid amide - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Hydrocarbon derivative - Organic sodium salt - Organic salt - Carbonyl group - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. |
| External Descriptors | Not available |
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Cibles associées (humaines)
LDHA
Tchem
L-lactate dehydrogenase A chain (1573 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2D6
Tclin
Cytochrome P450 2D6 (33882 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP1A2
Tchem
Cytochrome P450 1A2 (26471 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2C9
Tchem
Cytochrome P450 2C9 (32119 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP2C19
Tchem
Cytochrome P450 2C19 (29246 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP3A4
Tclin
Cytochrome P450 3A4 (53859 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MCF7 (126967 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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A549 (127892 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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MIA PaCa-2 (5949 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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BLM
Tchem
Bloom syndrome protein (4248 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mécanismes d'action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | Références |
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Noms et identifiants
| Pubchem Sid | 488179888 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179888 |
| IUPAC Name | sodium;oxamate |
| INCHI | InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1 |
| InChIKey | RQVZIJIQDCGIKI-UHFFFAOYSA-M |
| Smiles | C(=O)(C(=O)[O-])N.[Na+] |
| Isomères SMILES | C(=O)(C(=O)[O-])N.[Na+] |
| PubChem CID | 5242 |
| Poids moléculaire | 111.03 |
| Beilstein | 6538153 |
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Article |
|---|---|---|---|
 D2525377 |
Certificate of Analysis | Apr 14, 2025 | S123221 |
| D2525378 |
Certificate of Analysis | Apr 14, 2025 | S123221 |
| D2525379 |
Certificate of Analysis | Apr 14, 2025 | S123221 |
| D2525380 |
Certificate of Analysis | Apr 14, 2025 | S123221 |
| F2330655 |
Certificate of Analysis | May 31, 2023 | S123221 |
| F2330586 |
Certificate of Analysis | May 31, 2023 | S123221 |
| F2330658 |
Certificate of Analysis | May 31, 2023 | S123221 |
| F2330583 |
Certificate of Analysis | May 31, 2023 | S123221 |
| F2330656 |
Certificate of Analysis | May 31, 2023 | S123221 |
| D2509064 |
Certificate of Analysis | May 31, 2023 | S123221 |
| F2330579 |
Certificate of Analysis | May 31, 2023 | S123221 |
| F2330653 |
Certificate of Analysis | May 11, 2023 | S123221 |
| C2330799 |
Certificate of Analysis | Apr 06, 2023 | S123221 |
| C2330804 |
Certificate of Analysis | Apr 06, 2023 | S123221 |
| C2330812 |
Certificate of Analysis | Apr 06, 2023 | S123221 |
| C2330807 |
Certificate of Analysis | Apr 06, 2023 | S123221 |
| J2222523 |
Certificate of Analysis | Jul 18, 2022 | S123221 |
| J2222524 |
Certificate of Analysis | Jul 18, 2022 | S123221 |
| J2222106 |
Certificate of Analysis | Jul 18, 2022 | S123221 |
| C2218342 |
Certificate of Analysis | Feb 14, 2022 | S123221 |
| C2218338 |
Certificate of Analysis | Feb 14, 2022 | S123221 |
| C2218340 |
Certificate of Analysis | Feb 14, 2022 | S123221 |
| C2218339 |
Certificate of Analysis | Feb 14, 2022 | S123221 |
| F2223131 |
Certificate of Analysis | Feb 14, 2022 | S123221 |
| D2121307 |
Certificate of Analysis | Apr 25, 2021 | S123221 |
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Propriétés chimiques et physiques
| Solubilité | Soluble in water (10 mg/ml) |
|---|---|
| Poids moléculaire | 111.030 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 110.993 Da |
| Monoisotopic Mass | 110.993 Da |
| Topological Polar Surface Area | 83.200 Ų |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 90.900 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
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Sodium oxamateÀ partir de 69,90 $US
Citations of This Product
| 1. Jin Nan, Bi Aiwei, Lan Xiaojing, Xu Jun, Wang Xiaomin, Liu Yingluo, Wang Ting, Tang Shuai, Zeng Hanlin, Chen Ziqi, Tan Minjia, Ai Jing, Xie Hua, Zhang Tao, Liu Dandan, Huang Ruimin, Song Yue, Leung Elaine Lai-Han, Yao Xiaojun, Ding Jian, Geng Meiyu, Lin Shu-Hai, Huang Min. (2019) Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer. Nature Communications, 10 (1): (1-15). |
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