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Sodium oxamate - 10mM in Water, high purity , CAS No.565-73-1

1 Citations COA COA
    Grade & Purity:
  • 10mM in Water
In stock
Item Number
S424787
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S424787-1ml
1ml
Available within 8-12 weeks(?)
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$69.90
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Weak lactate dehydrogenase inhibitor

View related series
Apoptosis (4276) Compound libraries (12325) Glucose Metabolism (1943)

Basic Description

Synonyms sodium oxamate | 565-73-1 | Oxamic acid sodium salt | Sodium 2-amino-2-oxoacetate | Aminooxoacetic acid sodium salt | Oxamic acid, sodium salt | Acetic acid, aminooxo-, monosodium salt | Oxamate (sodium) | Oxamic acid (sodium) | MFCD00044553 | sodium;oxamate | Oxalic acid mono
Specifications & Purity 10mM in Water
Biochemical and Physiological Mechanisms Weak lactate dehydrogenase inhibitor (IC 50 values are 600 and 4400 μM in H460 and A549 cells respectively). Inhibits glycolysis and gluconeogenesis. Pyruvate analog. Decreases extracellular acidification rate.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Sodium oxamate is an inhibitor of gluconeogenesis and glycolysis. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.
An inhibitor of gluconeogenesis useful for anticancer research

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives
Direct Parent Alpha amino acids and derivatives
Alternative Parents Primary carboxylic acid amides  Carboxylic acid salts  Monocarboxylic acids and derivatives  Carboxylic acids  Organopnictogen compounds  Organonitrogen compounds  Organic sodium salts  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic acyclic compounds
Substituents Alpha-amino acid or derivatives - Carboxamide group - Carboxylic acid salt - Primary carboxylic acid amide - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Hydrocarbon derivative - Organic sodium salt - Organic salt - Carbonyl group - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
External Descriptors Not available

Associated Targets(Human)

LDHA Tchem L-lactate dehydrogenase A chain (1573 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name sodium;oxamate
INCHI InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1
InChIKey RQVZIJIQDCGIKI-UHFFFAOYSA-M
Smiles C(=O)(C(=O)[O-])N.[Na+]
Isomeric SMILES C(=O)(C(=O)[O-])N.[Na+]
PubChem CID 5242
Molecular Weight 111.03
Beilstein 6538153

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Molecular Weight 111.030 g/mol
XLogP3
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 1
Exact Mass 110.993 Da
Monoisotopic Mass 110.993 Da
Topological Polar Surface Area 83.200 Ų
Heavy Atom Count 7
Formal Charge 0
Complexity 90.900
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Jin Nan, Bi Aiwei, Lan Xiaojing, Xu Jun, Wang Xiaomin, Liu Yingluo, Wang Ting, Tang Shuai, Zeng Hanlin, Chen Ziqi, Tan Minjia, Ai Jing, Xie Hua, Zhang Tao, Liu Dandan, Huang Ruimin, Song Yue, Leung Elaine Lai-Han, Yao Xiaojun, Ding Jian, Geng Meiyu, Lin Shu-Hai, Huang Min.  (2019)  Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.  Nature Communications,  10  (1): (1-15). 

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